FOOD ANALYSIS BY HPLC
CONTENTS CHAPTER PHYTOESTROGENS IN HEALTH: THE ROLE OF ISO?AVONES INTRODUCTION ABSORPTION, METABOLISM AND EXCRETION OF ISO?AVONES MECHANISMS OF ACTION OF ISO?AVONES CLINICAL E?ECTS OF ISO?AVONES CARDIOVASCULAR HEALTH THE BRAIN BONE HEALTH BREAST CANCER PROSTATE CANCER MENOPAUSAL SYMPTOMS AREAS IN DISPUTE SUMMARY POINTS KEY FACTS LIST OF ABBREVIATIONS REFERENCES CHAPTER PHYTOESTROGENS IN PLANTS: WITH SPECIAL REFERENCE TO ISO?AVONES CHARACTERIZATION OF PHYTOESTROGENS DISTRIBUTION OF PHYTOESTROGENS IN THE PLANT KINGDOM PHYTOESTROGENS OTHER THAN ISO?AVONES ISO?AVONES CHEMICAL FEATURES OF PLANT ISO?AVONES BIOSYNTHESIS OF ISO?AVONES LOCALISATION OF ISO?AVONES IN PLANTS BIOLOGICAL FUNCTION OF ISO?AVONES IN PLANTS INTERACTION OF ISO?AVONES WITH MICRO-ORGANISMS OF THE RHIZOSPHERE ISO?AVONES AS PHYTOALEXINS AND PHYTOANTICIPINS DE?NITIONS OF WORDS AND TERMS ISO?AVONES IN FOODS AND INGESTION IN THE DIET AN OVERVIEW OF STRUCTURE AND ANALYSIS OF DIETARY ISO?AVONES STRUCTURE ANALYSIS ISO?AVONE CONTENT IN SELECTED FOODS GROWTH, VARIETY, ENVIRONMENTAL AND POST-HARVEST STORAGE CONDITIONS A?ECTING ISO?AVONE COMPOSITION IN SOYBEANS ISO?AVONE COMPOSITION AS A?ECTED BY PROCESSING CHEMISTRY AND BIOCHEMISTRY CHAPTER THE CHEMISTRY/BIOCHEMISTRY OF THE BIOCONVERSION OF ISO?AVONES IN FOOD PREPARATION BIOCONVERSION OF ISO?AVONES FROM GLYCOSIDES TO AGLYCONES ENZYMATIC TRANSFORMATION OF ISO?AVONE ISOMERS IN FERMENTED SOYMILK B-GLYCOSIDASE REACTION DURING BIOCONVERSION OF ISO?AVONES DE?NITIONS OF WORD AND TERMS CHEMISTRY AND SYNTHESIS OF DAIDZEIN AND ITS METHYLATED DERIVATIVES: FORMONONETIN, ISOFORMONONETIN, AND DIMETHYLDAIDZEIN SYNTHESIS OF DAIDZEIN (1) SYNTHESIS OF DAIDZEIN: BF3 OET2-CATALYZED FRIEDEL–CRAFTS ACYLATION AND RING CLOSURE SYNTHESIS OF DAIDZEIN: RCM WITH GRUBBS’ CATALYST SYNTHESIS OF DAIDZEIN: I2-MEDIATED CYCLIZATION SYNTHESIS OF DAIDZEIN: OXIDATIVE REARRANGEMENT WITH THALLIUM(III) NITRATE SYNTHESIS OF FORMONONETIN (2) CARBONYLS AS ONE-CARBON ELECTROPHILES ACTIVATED ALDEHYDE SURROGATES AS ONE-CARBON SURROGATES SYNTHESIS OF ISOFORMONONETIN (3) SELECTIVE METHYLATION OF DAIDZEIN (1) SUZUKI-MEDIATED SYNTHESIS SYNTHESIS OF DIMETHYLDAIDZEIN (4) SYNTHESIS OF DIMETHYLDAIDZEIN: POLYMER-SUPPORTED IODOBENZENE DIACETATE (PSIBD)-PROMOTED OXIDATIVE REARRANGEMENT SYNTHESIS OF DIMETHYLDAIDZEIN: ORGANOLEAD-MEDIATED ARYLATION NON-NATURAL ISO?AVONOIDS PHENYLPROPANOID AND ISO?AVONOID PATHWAYS ISO?AVANOIDS SEMI-SYNTHESIS OF NON-NATURAL ISO?AVONOIDS CHEMICAL SYNTHESIS OF NON-NATURAL FLAVANONES ER ASSAY PROTEIN ENGINEERING OF URIDINE DIPHOSPHATE GLYCOSLYTRANSFERASE (UGT) STRUCTURAL AND FUNCTIONAL STUDIES OF IFS THE STRUCTURE OF ISO?AVONES BY 1D AND 2D HOMONUCLEAR AND HETERONUCLEAR NMR SPECTROSCOPY STRUCTURE ELUCIDATION: ESTABLISHING SPECTRAL CORRELATIONS CHROMATOGRAPHY-NMR CONFORMATION AND NMR SUBSTITUENT E?ECTS AND PREDICTION OF STRUCTURES ISO?AVONE METABOLITES SOLVENT E?ECTS ACKNOWLEDGEMENT BIOTRANSFORMATION AND TRANSFER OF GENISTEIN: A COMPARISON WITH XENOESTROGENS AND A FOCUS ON THE HUMAN PLACENTA BIOTRANSFORMATION OF GENISTEIN COMPOUNDS IN THE GASTROINTESTINAL TRACT DEGLYCOSYLATION OF GENISTIN IN THE SMALL INTESTINE GLUCURONIDATION AND SULFATION OF GENISTEIN HYDROXYLATION OF GENISTEIN IN THE LIVER BREAKDOWN OF GENISTEIN AND LUMINAL EXCRETION TRANSFER OF GENISTEIN IN PLACENTA A COMPARISON WITH OTHER XENOESTROGENS CHEMICAL STRUCTURE OF BPA AND NP BIOTRANSFORMATION OF XENOESTROGENS PLACENTA TRANSFER CONCLUSION THE BIOLOGICAL E?ECTS OF GENISTEIN AND ITS INTRACELLULAR METABOLITE, 5,7,30,40-TETRAHYDROXYISO?AVONE GENISTEIN AND ITS BIOLOGICAL ACTIVITIES OESTROGENIC ACTIVITY ANTICANCER E?ECTS ANTIOXIDANT ACTION ANTI-IN?AMMATORY ACTIVITY INTRACELLULAR FORMATION OF THE GENISTEIN METABOLITE 5,7,30,40-TETRAHYDROXYISO?AVONE (THIF) THIF AND CANCER THIF AND ENDOTHELIAL FUNCTION SUMMARY CHAPTER 10 GENISTEIN CHEMISTRY AND BIOCHEMISTRY CHEMICAL STRUCTURE AND INTERACTION WITH ESTROGEN RECEPTORS METABOLISM CHAPTER 11 ISO?AVONES AND HUMAN ESTROGEN RECEPTOR: WHEN PLANTS SYNTHESIZE MAMMALIAN HORMONE MIMETICS FROM PLANT BIOSYNTHESIS TO MAMMALIAN BIOSYNTHESIS BIOSYNTHESIS OF ISO?AVONOIDS IN LEGUMINOUS CELLS BIOSYNTHESIS OF ISO?AVONOIDS IN ERS INTERACTION OF ISO?AVONOIDS WITH ERS MAMMALIAN METABOLISM AND BIOAVAILABILITY BIOCHEMICAL AND PHYSIOLOGICAL FUNCTIONS OF ISO?AVONOIDS ESTROGENIC-RELATED E?ECTS NON-ESTROGENIC-RELATED E?ECTS ANALYSIS CHAPTER 12 CONTINUOUS MICROWAVE-ASSISTED ISO?AVONE EXTRACTION MICROWAVE EXTRACTION SYSTEM DESIGNS MICROWAVE-ASSISTED EXTRACTION PROCESS OIL SEPARATION AND ISO?AVONE PURI?CATION SIGNI?CANT RESULTS AND DISCUSSION ISO?AVONES (AND OIL) YIELDS IN?UENCE OF TIME AND TEMPERATURE ON THE OIL AND ISO?AVONES EXTRACTION YIELD – REACTION KINETICS ACKNOWLEDGEMENTS CHAPTER 13 ISO?AVONES: HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF GLUCURONIC ACID- AND SULFURIC ACID-CONJUGATED METABOLITES OF DAIDZEIN AND GENISTEIN IN HUMAN PLASMA AND URINE CONVENTIONAL METHODS SELECTIVE ENZYMATIC HYDROLYSIS FRACTIONATION BY ION-EXCHANGE CHROMATOGRAPHY DIRECT ASSAY A SIMPLE DIRECT ASSAY OF CONJUGATED METABOLITES USING HPLC-UV REFERENCE COMPOUNDS SPE CHROMATOGRAPHIC CONDITIONS APPLICATION CHAPTER 14 HIGH-THROUGHPUT QUANTI?CATION OF PHARMACOLOGICALLY ACTIVE ISO?AVONES USING LC-UV/PDA AND LC-MS/MS HIGH-THROUGHPUT HPLC-UV/MS ANALYTICAL/BIOANALYTICAL METHODS HIGH-THROUGHPUT HPLC METHODS USING UV DETECTION HIGH-THROUGHPUT HPLC METHODS USING MS CONCLUSIONS CHAPTER 15 METHODS FOR ISO?AVONES: A FOCUS ON BEVERAGE ANALYSIS METHODS OF EXTRACTION DIRECT EXTRACTION HYDROLYSIS INTERNAL STANDARDS CHROMATOGRAPHIC METHODS CHAPTER 16 THE DETERMINATION OF ISO?AVONES IN SUPPLEMENTED FOODS: AN OVERVIEW ISO?AVONE ISOLATION TECHNIQUES FOR THE ANALYSIS OF ISO?AVONES IN SUPPLEMENTED FOOD LIQUID CHROMATOGRAPHY (LC) GAS GHROMATOGRAPHY (GC) CAPILLARY ELECTROPHORESIS (CE) MASS SPECTROMETRY (MS) IMMUNOANALYSIS DE?NITION OF WORDS AND TERMS CHAPTER 17 ISO?AVONES: LC-MS/MS PRO?LING OF ISO?AVONE GLYCOSIDES AND OTHER CONJUGATES CHROMATOGRAPHIC SEPARATION OF FLAVONOIDS MASS SPECTROMETRY (MS) AS A TOOL FOR IDENTI?CATION OF ISO?AVONE GLYCOCONJUGATES SOURCES OF STRUCTURAL VARIABILITY OF FLAVONOID COMPOUNDS DI?ERENTIATION OF ISO?AVONE AND FLAVONE GLYCOCONJUGATES WITH INSTRUMENTAL METHODS DI?ERENTIATION OF C-GLYCOSIDES AND O-GLYCOSIDES OF ISO?AVONOIDS DI?ERENTIATION OF ACYLATED GLYCOCONJUGATES OF ISO?AVONOIDS CHAPTER 18 PUERARIAE RADIX ISO?AVONES USE OF RESOURCES CHEMICAL COMPOSITION PHARMACOLOGY AND POTENTIAL APPLICATIONS ANTI-TUMOR ACTIVITY ANTI-IN?AMMATION ANTI-HYPERTENSION ANTI-ATHEROSCLEROSIS NEUROPROTECTION ANTI-ALLERGY ANTI-HYPERGLYCEMIC E?ECT CHAPTER 19 PATTERN PRO?LING AND QUANTITATIVE DETERMINATION OF ISO?AVONES IN HERBAL CHEMOTYPES USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY HERBAL PREPARATIONS FOR OSTEOPOROSIS PATTERN PRO?LING AND QUANTITATIVE ANALYSIS OF HERBAL FRACTIONS OSTEOGENIC HERBAL FRACTIONS AND COMPOUNDS OF BUTEA MONOSPERMA LC-MS/MS METHOD FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF HERBAL FRACTIONS MASS SPECTROMETRIC CONDITIONS VALIDATION OF THE LC-MS/MS METHOD PATTERN PRO?LING AND QUANTITATIVE ANALYSIS OF ISO?AVONES CHAPTER 20 ANALYSIS OF NOVEL ISO?AVONE DIGYCOSIDE IN NUTS ISO?AVONES IN GROUNDNUTS PLANT MATERIAL AND PREPARATION OF GROUNDNUT EXTRACT HPLC ANALYSIS OF ISO?AVONES ISOLATION AND PURI?CATION OF A NOVEL ISO?AVONE FROM GROUNDNUT EXTRACT CONTENT OF A NOVEL ISO?AVONE IN GROUNDNUTS ANALYTICAL PRO?LES OF GROUNDNUTS ISO?AVONE PRO?LE OF GROUNDNUTS IN?UENCE OF THE EXTRACTION TEMPERATURE ON THE ISO?AVONE COMPOSITION OF GROUNDNUT EXTRACT PURI?CATION OF A NOVEL ISO?AVONE (PEAK-1) FROM THE GROUNDNUT EXTRACT STRUCTURAL ANALYSIS OF A NOVEL ISO?AVONE FROM THE GROUNDNUT EXTRACT CONTENT OF A NOVEL ISO?AVONE FROM THE GROUNDNUT EXTRACT FUNCTION AND E?ECTS CHAPTER 21 ISO?AVONE INGESTION BY MULTIETHNIC POPULATIONS: IMPLICATIONS FOR HEALTH ISO?AVONE INGESTION BY MULTIETHNIC POPULATIONS AUSTRALIA AND THE UK BRAZIL CANADA CHINA AND HONG KONG ITALY JAPAN KOREA SINGAPORE AND INDONESIA TAIWAN USA CHAPTER 22 ISO?AVONES IN BEVERAGES ISO?AVONE SOURCES BEVERAGES AS ISO?AVONE SOURCES CHAPTER 23 USE OF ISO?AVONES IN INHERITED METABOLIC DISEASES: A FOCUS ON MUCOPOLYSACCHARIDOSES GENERAL INTRODUCTION INTRODUCTION ON MUCOPOLYSACCHARIDOSES (MPS) CLINICAL INFORMATION, GENETICS AND BIOCHEMISTRY PATHOPHYSIOLOGY INTRODUCTION ON GLYCOSAMINOGLYCAN (GAGS) AND ISO?AVONE FAMILIES GAGS: STRUCTURE, FUNCTION AND LIFE CYCLE ISO?AVONE FAMILY: STRUCTURE, FUNCTION AND LIFE CYCLE USE OF ISO?AVONES FOR SUBSTRATE REDUCTION THERAPY (SRT) SUBSTRATE REDUCTION THERAPY (SRT): DE?NITION ISO?AVONES AND ANALOGS ARE POTENT AGENTS FOR SRT ISO?AVONE ACTION ON GAG SYNTHESIS AND GAG ACCUMULATION CONCLUSIONS AND PERSPECTIVES FOR THE CLINIC CHAPTER 24 OPTIMIZING ISO?AVONE-RICH FOOD DELIVERY SYSTEMS FOR HUMAN CLINICAL TRIALS DELIVERY OF ISO?AVONE DOSAGE WITHOUT COMPROMISING PALATABILITY PROCESSING E?ECTS ON SOY ISO?AVONES RELEVANCE OF ISO?AVONE CHEMICAL COMPOSITION MATERIALS AND METHODS PREPARATION OF FERMENTED AND THERMALLY TREATED SOY INGREDIENTS SOY-ALMOND BREAD (SAB) PREPARATION ISO?AVONE ANALYSIS PHYSICOCHEMICAL EXPERIMENTS CHARACTERIZATION OF ORGANOLEPTIC PROPERTIES RESULTS AND DISCUSSION PROCESS OF SELECTING THE OPTIMAL PHYTOCHEMICAL DELIVERY VEHICLE PHYSICOCHEMICAL PROPERTIES CHAPTER 25 ISO?AVONES AND THYROID FUNCTION: AN OVERVIEW GOITROGENIC E?ECTS OF FLAVONOIDS THE CASE OF GENISTEIN GENISTEIN AND THYROID FUNCTION CHAPTER 26 ISO?AVONES AGAINST GASTRIC CANCER: FUNCTION AND E?ECTS ABSORPTION, METABOLISM, AND EXCRETION FUNCTION AND E?ECT OF ISO?AVONES AGAINST GASTRIC CANCER ANTI-BACTERIAL E?ECTS ANTIOXIDANT ACTIVITY ANTI-IN?AMMATION E?ECT INHIBITION OF ENZYMES INHIBITION OF ANGIOGENESIS ENHANCEMENT OF APOPTOSIS EVIDENCE FROM POPULATION STUDIES CHAPTER 27 DIETARY ISO?AVONES AND LEARNING AND MEMORY PRE-CLINICAL STUDIES OF THE DELETERIOUS, ENDOCRINE-DISRUPTING E?ECTS OF DIETARY ISO?AVONES ON LEARNING AND MEMORY PRE-CLINICAL STUDIES OF THE BENE?CIAL E?ECTS OF DIETARY ISO?AVONES IN RODENT MODELS OF AGE-ASSOCIATED COGNITIVE DE?CITS PRE-CLINICAL STUDIES OF BENE?CIAL E?ECTS OF DIETARY ISO?AVONES IN OVARIECTOMIZED RATS HUMAN CLINICAL STUDIES OF BENE?CIAL E?ECTS OF DIETARY ISO?AVONES ON LEARNING AND MEMORY CHAPTER 28 GLYCITEIN IN HEALTH ABSORPTION GLYCITEIN AND BONE HEALTH GLYCITEIN AND CANCER GLYCITEIN AND CARDIOVASCULAR HEALTH GLYCITEIN AS AN ESTROGEN RECEPTOR (ER) AGONIST GLYCITEIN AND MEMORY AND MOOD GLYCITEIN AND OXIDATIVE STRESS CHAPTER 29 ISO?AVONES AND PRENATAL EXPOSURE TO EQUOL BACKGROUND: POLYPHENOLS AND ISO?AVONOIDS ISO?AVONOID METABOLISM IN MAMMALS: POSTNATAL DEVELOPMENT EQUOL: BIOSYNTHESIS (PLANTS AND MAMMALS), ANTIOXIDANT ACTIVITY, AND SAFETY DATA IN POSTNATAL DEVELOPMENT COMPARISON BETWEEN HUMAN AND RAT: NEWBORN AND ADULT PARAMETERS PERINATAL STUDIES AND TRANSPLACENTAL TRANSPORT OF ISO?AVONOIDS ISO?AVONOIDS: PERINATAL RODENT STUDIES EQUOL: PERINATAL RODENT STUDIES ISO?AVONOIDS: PERINATAL HUMAN STUDIES SUMMARY AND CONSIDERATIONS CHAPTER 30 GENISTEIN: GABAA AND NMDA RECEPTORS GABAA RECEPTOR FUNCTION AND STRUCTURE GABAA RECEPTOR FUNCTION GABAA RECEPTOR STRUCTURE GABAA RECEPTOR MODULATION GENISTEIN MODULATION OF GABA RECEPTORS GENISTEIN AS AN INHIBITOR OF PROTEIN TYROSINE KINASES (PTKS) DIRECT INHIBITION OF GABAA RECEPTORS NMDA RECEPTOR FUNCTION, STRUCTURE AND MODULATION NMDA RECEPTOR FUNCTION NMDA RECEPTOR STRUCTURE NMDA RECEPTOR MODULATION GENISTEIN MODULATES NMDA RECEPTOR MODULATION DIRECT INHIBITION OF NMDA RECEPTORS GENISTEIN MODULATION OF GABAA AND NMDA RECEPTORS VIA THE ESTROGENIC PATHWAY FUNCTIONAL IMPLICATIONS CHAPTER 31 ESTROGENIC ACTIVITY AND MOLECULAR MECHANISMS OF COUMESTROL-INDUCED BIOLOGICAL E?ECTS ANIMAL STUDIES MECHANISMS OF THE TOXIC ACTION HUMAN STUDIES INTERPRETATION OF DATA IN RELATION TO HUMAN EXPOSURE CHAPTER 32 GENISTEIN AND INSULIN SECRETORY FUNCTION GENISTEIN MAY HAVE ANTI-DIABETIC E?ECTS GENISTEIN AT PHYSIOLOGICAL CONCENTRATIONS AUGMENTS GLUCOSE-STIMULATED INSULIN SECRETION (GSIS) IN BETA-CELLS AND PANCREATIC ISLETS CHAPTER 33 PREVENTION AND MANAGEMENT OF OBESITY BY ISO?AVONES EVIDENCE THAT DIETARY FACTORS AND SOY ISO?AVONES PLAY A ROLE IN OBESITY INTRODUCTION TO SOY PHYTOCHEMICALS AND ISO?AVONES POPULATION-BASED STUDIES LABORATORY STUDIES IDENTI?CATION AND MECHANISM OF SOY ISO?AVONES WITH ANTI-OBESITY ACTIVITIES MODULATION OF FAT DEPOSITION AND ADIPOGENESIS BY SOY ISO?AVONES A FACILE STRATEGY FOR THE IDENTI?CATION OF SOY ISO?AVONES WITH POTENTIAL FOR REGULATING VISCERAL FAT DISCOVERY OF PROTEINS TARGETED BY SOY ISO?AVONES WITH A REGULATORY ROLE IN ADIPOGENESIS CANDIDATE MOLECULAR TARGETS AND MECHANISMS OF ANTI-OBESITY ISO?AVONES: INTERPLAY BETWEEN NQO1 AND P53 IN REGULATION OF ADIPOGENESIS ROLE OF PPARA, PPARG, C/EBPA AND OTHER CANDIDATE MOLECULAR SENSORS/E?ECTORS OF ADIPOGENESIS CHAPTER 34 SOY ISO?AVONES AND TESTICULAR FUNCTION DIETARY SOURCES OF ISO?AVONES HORMONAL REGULATION OF REPRODUCTIVE TRACT DEVELOPMENT REGULATION OF GONADAL FUNCTION ISO?AVONE ACTION IN TESTICULAR CELLS E?ECTS ON STEROIDOGENESIS E?ECTS ON SPERM PRODUCTION E?ECTS ON DEVELOPING VERSUS MATURE STAGES OF DEVELOPMENT MECHANISMS OF ISO?AVONE ACTION ISO?AVONE ACTION IN THE HUMAN TESTIS CHAPTER 35 EQUOL AND CELL PROLIFERATION EQUOL AND HORMONE-POSITIVE CELL PROLIFERATION EQUOL BINDS TO ERS WITH A GREATER A?NITY THAN DAIDZEIN ESTROGENIC ACTIVITY AND BREAST CANCER EQUOL AND PROSTATE CANCER EQUOL AND THE REPRODUCTIVE SYSTEM EQUOL AND NEUROPROTECTION EQUOL AND OTHER CANCER CELL PROLIFERATION EQUOL AND PANCREATIC CANCER EQUOL AND COLON CANCER EQUOL AND CVDS EQUOL AND IMMUNE FUNCTIONS EQUOL AND GENOTOXICITY EQUOL AND CELL INVASION EQUOL AND CANCER CHEMOPREVENTION EQUOL AND DRUG METABOLISM GENERAL CONCLUSIONS CHAPTER 36 BONE, GENISTEIN, DAIDZEIN AND EQUOL BONE AND ESTROGEN BONE AND SOY ISO?AVONES BONE AND PURI?ED GENISTEIN, DAIDZEIN AND EQUOL CHAPTER 37 ISO?AVONES AND IN?AMMATION IN ADIPOSE TISSUE AND IMPLICATIONS FOR HEALTH AN INTRODUCTION TO IN?AMMATION IN ADIPOSE TISSUE AN OVERVIEW OF ISO?AVONES AS ANTI-IN?AMMATORY AGENTS ISO?AVONES CAN MODULATE PROIN?AMATORY FACTORS IN MACROPHAGES AND ADIPOCYTES AND DOWN-REGULATE GENE EXPRESSION OF PROIN?AMMATORY MEDIATORS ISO?AVONES CAN MODULATE PROIN?AMATORY FACTORS IN ADIPOSE TISSUE BY A DECREASE IN ADIPOSE TISSUE MASS AND/OR NUMBER WHAT WE KNOW FROM ANIMAL MODELS AND ISO?AVONE E?ECTS ON ADIPOSE TISSUE IN?AMMATION AND HEALTH THE E?ECTS OF ISO?AVONES IN ANIMAL MODELS OF OBESITY: E?ECT OF ISO?AVONES IN RATS WITH HIGH-FAT DIET (HFD)-INDUCED OBESITY/INSULIN RESISTANCE AND THE ANALYSIS OF IN?AMMATORY FACTORS WHAT WE KNOW FROM HUMAN STUDIES AND THE E?ECTS OF ISO?AVONE ON ADIPOSE TISSUE IN?AMMATION STUDIES IN OBESE POSTMENOPAUSAL WOMEN STUDIES WITH GENISTEIN (GEN) IN HUMAN CELL IN?AMMATION CHAPTER 38 ISO?AVONES FOR MENOPAUSAL VASOMOTOR SYNDROME PHARMACOLOGY ASPECTS CLINICAL EVIDENCE LIST OF ABBREVIATION