Latest Findings in Dna and Rna Science
Preface....................................................................................................................................................................VII Chapter 1 Design of the Crosslinking Reactions for Nucleic Acids-Binding Protein and Evaluation of the Reactivity..................................................................................................................................1 Kenta Odaira, Ken Yamada, Shogo Ishiyama, Hidenori Okamura and Fumi Nagatsugi Chapter 2 De Novo Nucleic Acids: A Review of Synthetic Alternatives to DNA and RNA that could Act as Bio-Information Storage Molecules.........................................................................15 Kevin G Devine and Sohan Jheeta Chapter 3 Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation..............................................................................................................................35 Hajnalka Andrikovics, Zoltán ?rfi, Nóra Meggyesi, András Bors, Lívia Varga, Petra Kövy, Zsófia Vilimszky, Fanni Kolics, László Gopcsa, Péter Reményi and Attila Tordai Chapter 4 Identification of Structural Variation from NGS-Based Non-Invasive Prenatal Testing...........................................................................................................................54 Ondrej Pös, Jaroslav Budis, Zuzana Kubiritova, Marcel Kucharik, Frantisek Duris, Jan Radvanszky and Tomas Szemes Chapter 5 Cell-Free, Embryo-Specific sncRNA as a Molecular Biological Bridge between Patient Fertility and IVF Efficiency....................................................................................................................62 Angelika V. Timofeeva, Vitaliy V. Chagovets, Yulia S. Drapkina, Nataliya P. Makarova, Elena A. Kalinina and Gennady T. Sukhikh Chapter 6 Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management..................................................................................................................86 Pavol Zubor, Peter Kubatka, Karol Kajo, Zuzana Dankova, Hubert Polacek, Tibor Bielik, Erik Kudela, Marek Samec, Alena Liskova, Dominika Vlcakova, Tatiana Kulkovska, Igor Stastny, Veronika Holubekova, Jan Bujnak, Zuzana Laucekova, Dietrich Büsselberg, Mariusz Adamek, Walther Kuhn, Jan Danko and Olga Golubnitschaja Chapter 7 Aberrant Methylation Status of Tumour Suppressor Genes in Ovarian Cancer Tissue and Paired Plasma Samples..................................................................................................................116 Dana Dvorská, Dušan Braný, Bálint Nagy, Marián Grendár, Robert Poka, Beáta Soltész, Marianna Jagelková, Katarína Zelinová, Zora Lasabová, Pavol Zubor and Zuzana Danková Chapter 8 Combination of Fetal Fraction Estimators Based on Fragment Lengths and Fragment Counts in Non-Invasive Prenatal Testing....................................................................................135 Juraj Gazdarica, Rastislav Hekel, Jaroslav Budis, Marcel Kucharik, Frantisek Duris, Jan Radvanszky, Jan Turna and Tomas Szemes Chapter 9 Cell-Free Nucleic Acids and their Emerging Role in the Pathogenesis and Clinical Management of Inflammatory Bowel Disease...............................................................................147 Zuzana Kubiritova, Jan Radvanszky and Roman Gardlik Chapter 10 Sex, Age and Bodyweight as Determinants of Extracellular DNA in the Plasma of Mice..............................................................................................................................................168 ?ubica Janovi?ová, Barbora Kone?ná, Lenka Vokálová, Lucia Lauková, Barbora Vlková and Peter Celec Chapter 11 Circulating miRNA Profiling in Plasma Samples of Ovarian Cancer Patients.......................................176 András Penyige, Éva Márton, Beáta Soltész, Melinda Szilágyi-Bónizs, Róbert Póka, János Lukács, Lajos Széles and Bálint Nagy Chapter 12 Exosomes-Associated DNA—New Marker in Pregnancy Complications?..............................................194 Barbora Kone?ná, ?ubomíra Tóthová and Gabriela Repiská Chapter 13 Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri..................................................................................................................................209 Dana Dvorská, Henrieta Škovierová, Dušan Braný, Erika Halašová and Zuzana Danková Permissions List of Contributors Index Contents