Understanding and Using Genetic Information
Preface....................................................................................................................................................................VII Chapter 1 Identification of Novel Causal FBN1 Mutations in Pedigrees of Marfan Syndrome................................ 1 Yueli Wang, Xiaoyan Li, Rongjuan Li, Ya Yang and Jie Du Chapter 2 Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice..................................................................................................... 9 Kamila Borowczyk, Jacek Wróblewski, Joanna Suliburska, Noriyuki Akahoshi, Isao Ishii and Hieronim Jakubowski Chapter 3 Prediction of Blood Lipid Phenotypes using Obesity-Related Genetic Polymorphisms and Lifestyle Data in Subjects with Excessive Body Weight.......................................... 16 Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro, Marta Cuervo, Leticia Goni and J. A. Martinez Chapter 4 The miRNA Pull Out Assay as a Method to Validate the miR-28-5p Targets Identified in other Tumor Contexts in Prostate Cancer................................................................................. 26 Milena Rizzo, Gabriele Berti, Francesco Russo, Monica Evangelista, Marco Pellegrini and Giuseppe Rainaldi Chapter 5 Insights on Genomic and Molecular Alterations in Multiple Myeloma and their Incorporation towards Risk-Adapted Treatment Strategy............................................................................ 33 Taiga Nishihori and Kenneth Shain Chapter 6 Protein Engineering Strategies to Expand CRISPR-Cas9 Applications..................................................... 39 Lucas F. Ribeiro, Liliane F. C. Ribeiro, Matheus Q. Barreto and Richard J. Ward Chapter 7 Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine.................................................. 51 Jihye Kim, Minjae Yoo, Jimin Shin, Hyunmin Kim, Jaewoo Kang and Aik Choon Tan Chapter 8 The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics...................................................................................................................................................... 62 Preethi Krishnan and Sambasivarao Damaraju Chapter 9 Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing more Complete Coverage of Disease-Related Genes.................................................................................................................................... 79 Runyu Jing, Yu Liang, Yi Ran, Shengzhong Feng, Yanjie Wei and Li He Chapter 10 HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways..................................................................................................... 93 Hongliang Wang, Wei Xing, Shijie Tang, Zhenglin Wang, Tiantian Lv, Yan Wu, Shuzhen Guo, Chun Li, Jing Han, Ruixin Zhu and Wei Wang Chapter 11 Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chroni c Sleep Deprivation using Gas Chromatography-Mass Spectrometry....................................................... 104 Wei-ni Ma, Ming-mei Zhou, Xiao-jun Gou, Le Zhao, Fang Cen, Ying Xu and Hong-yi Shen Chapter 12 The Genetic Diversity and Geographic Differentiation of the Wild Soybean in Northeast China based on Nuclear Microsatellite Variation..................................................................... 115 Hongkun Zhao, Yumin Wang, Fu Xing, Xiaodong Liu, Cuiping Yuan, Guangxun Qi, Jixun Guo and Yingshan Dong Chapter 13 The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach............................................................................................................................................................... 123 Jesús Espinal-Enríquez, Daniel González-Terán and Enrique Hernández-Lemus Chapter 14 Identification and Characterization of the Diverse Stress-Responsive R2R3-RMYB Transcription Factor from Hibiscus sabdariffa L.................................................................. 135 Bahaeldeen Babikar Mohamed, Beenish Aftab, Muhammad Bilal Sarwar, Bushra Rashid, Zarnab Ahmad, Sameera Hassan and Tayyab Husnain Chapter 15 Gene Coexpression Network Comparison via Persistent Homology....................................................... 147 Ali Nabi Duman and Harun Pirim Chapter 16 Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and their Regulatory Network Nodes. ............................................................................................. 158 Guangxin Yuan, Yu Bai, Yuhang Zhang and Guangyu Xu Chapter 17 Transcriptome Analysis Reveals Dynamic Fat Accumulation in the Walnut Kernel...................................................................................................................................................... 167 Shuang Zhao, Xuemei Zhang, Yanping Su, Yilan Chen, Yang Liu, Meng Sun and Guohui Qi Chapter 18 Multiple Regression Analysis Reveals MicroRNA Regulatory Networks in Oryza sativa under Drought Stress................................................................................................................. 180 Jiajia Chen and Liangzhi Li Permissions List of Contributors Index Contents