BAYESIAN BIOSTATISTICS AND DIAGNOSTIC MEDICINE

By V. GAVIK

INTRODUCTION STATISTICAL METHODS IN DIAGNOSTIC MEDICINE PREVIEW OF BOOK DATASETS FOR THE BOOK SOFTWARE REFERENCES DIAGNOSTIC MEDICINE IMAGING MODALITIES ACTIVITIES IN DIAGNOSTIC IMAGING ACCURACY AND AGREEMENT DEVELOPMENTAL TRIALS FOR IMAGING PROTOCOL REVIEW AND CLINICAL TRIALS THE PROTOCOL PHASE I, II, AND III CLINICAL DESIGNS THE LITERATURE OTHER DIAGNOSTIC PROCEDURES SENTINEL LYMPH NODE BIOPSY FOR MELANOMA TUMOR DEPTH TO DIAGNOSE METASTATIC MELANOMA BIOPSY FOR NONSMALL CELL LUNG CANCER CORONARY ARTERY DISEASE BAYESIAN STATISTICS BAYES THEOREM PRIOR INFORMATION POSTERIOR INFORMATION INFERENCE ESTIMATION TESTING HYPOTHESES BINOMIAL EXAMPLE OF TESTING COMPARING TWO BINOMIAL POPULATIONS SHARP NULL HYPOTHESIS FOR THE NORMAL MEAN SAMPLE SIZE A ONE-SAMPLE BINOMIAL FOR RESPONSE A ONE-SAMPLE BINOMIAL WITH PRIOR INFORMATION COMPUTING DIRECT METHODS OF COMPUTATION GIBBS SAMPLING COMMON MEAN OF NORMAL POPULATIONS MCMC SAMPLING WITH WINBUGS® EXERCISES BAYESIAN METHODS FOR DIAGNOSTIC ACCURACY STUDY DESIGN OBJECTIVES BACKGROUND PATIENT AND READER SELECTION STUDY PLAN NUMBER OF PATIENTS STATISTICAL DESIGN AND ANALYSIS BAYESIAN METHODS FOR TEST ACCURACY: BINARY AND ORDINAL DATA CLASSI?CATION PROBABILITIES PREDICTIVE VALUES DIAGNOSTIC LIKELIHOOD RATIOS ROC CURVE BAYESIAN METHODS FOR TEST ACCURACY: QUANTITATIVE VARIABLES THE SPOKANE HEART STUDY ROC AREA DE?NITION OF THE ROC CURVE CHOICE OF OPTIMAL THRESHOLD VALUE CLUSTERED DATA: DETECTION AND LOCALIZATION BAYESIAN ROC CURVE FOR CLUSTERED INFORMATION CLUSTERED DATA IN MAMMOGRAPHY COMPARING ACCURACY BETWEEN MODALITIES SAMPLE SIZE DETERMINATION DISCRETE DIAGNOSTIC SCORES BINARY TESTS MULTINOMIAL OUTCOMES SAMPLE SIZES: CONTINUOUS DIAGNOSTIC SCORES ONE ROC CURVE TWO ROC CURVES REGRESSION AND TEST ACCURACY AUDIOLOGY STUDY LOG LINK FUNCTION LOGISTIC LINK DIAGNOSTIC LIKELIHOOD RATIO ROC AREA AND PATIENT COVARIATES ROC CURVE AS RESPONSE TO THERAPY DIAGNOSING PROSTATE CANCER AGREEMENT AGREEMENT FOR DISCRETE RATINGS BINARY SCORES OTHER INDICES OF AGREEMENT A BAYESIAN VERSION OF MCNEMAR COMPARING TWO KAPPA PARAMETERS KAPPA AND STRATI?CATION MULTIPLE CATEGORIES AND TWO READERS MULTIPLE CATEGORIES AGREEMENT AND COVARIATE INFORMATION AGREEMENT FOR A CONTINUOUS RESPONSE INTRA-CLASS CORRELATION COEF?CIENT ONE-WAY RANDOM MODEL TWO-WAY RANDOM MODEL REGRESSION AND AGREEMENT COMBINING READER INFORMATION DIAGNOSTIC IMAGING AND CLINICAL TRIALS CLINICAL TRIALS PHASE I DESIGNS PHASE II TRIALS PHASE III TRIALS PROTOCOL GUIDELINES FOR TUMOR RESPONSE BAYESIAN SEQUENTIAL STOPPING RULES SOFTWARE FOR CLINICAL TRIALS CRM SIMULATOR FOR PHASE I TRIALS MULTC LEAN FOR PHASE II TRIALS EXAMPLES PHASE I TRIAL FOR RENAL CELL CARCINOMA AN IDEAL PHASE II TRIAL PHASE II TRIAL FOR ADVANCED MELANOMA OTHER TOPICS IMPERFECT DIAGNOSTIC TEST PROCEDURES EXTREME VERI?CATION BIAS VERI?CATION BIAS ESTIMATING TEST ACCURACY WITH NO GOLD STANDARD TEST ACCURACY AND SURVIVAL ANALYSIS ROC CURVES WITH A NON-BINARY GOLD STANDARD PERIODIC SCREENING IN CANCER INFERENCE FOR SENSITIVITY AND TRANSITION PROBABILITY BAYESIAN INFERENCE FOR LEAD-TIME DECISION THEORY AND DIAGNOSTIC ACCURACY CHAPTER