THE DISEASES OF CHINA
PART 1: INTRODUCTION TO EMERGING INFECTIOUS DISEASES CHAPTER 1: INFECTIOUS DISEASES PAST AND PRESENT MAJOR CONCEPTS 4 HISTORY OF INFECTIOUS DISEASES 5 THE ROLE OF INFECTIOUS DISEASES IN THE WORLD TODAY 8 THE LINKS BETWEEN INFECTIOUS DISEASES, POVERTY, AND CIVIL UNREST 10 EMERGING AND REEMERGING INFECTIOUS DISEASES 12 FACTORS CONTRIBUTING TO THE EMERGENCE OF NEW INFECTIOUS DISEASES AND THE SPREAD AND EVOLUTION OF OLDER DISEASES 15 TIMELINE CHAPTER 2: OF MICROBES AND MEN MAJOR CONCEPTS 28 INTRODUCTION 30 INFECTIOUS AGENTS: THE ENEMY COMBATANTS 30 GENETIC INFORMATION AND THE MAKING OF PROTEINS: PREPARING THE ARMAMENT 36 THE IMMUNE RESPONSE: HUMANS FIGHT BACK, PART ONE 40 ANTIMICROBIAL AGENTS: HUMANS FIGHT BACK, PART TWO PART 2: BACTERIAL INFECTIONS CHAPTER 3: LYME DISEASE MAJOR CONCEPTS 56 INTRODUCTION 58 HISTORY 60 THE DISEASE THE CAUSATIVE AGENT 63 THE IMMUNE RESPONSE 66 DIAGNOSIS TREATMENT 68 PREVENTION 69 SURVEILLANCE CHAPTER 4: HUMAN EHRLICHIOSIS MAJOR CONCEPTS 76 INTRODUCTION 77 HISTORY 78 THE DISEASES THE CAUSATIVE AGENTS 88 THE IMMUNE RESPONSE DIAGNOSIS 90 TREATMENT 91 PREVENTION 92 SURVEILLANCE C O N T E N T S IV CHAPTER 5: BARTONELLA INFECTIONS MAJOR CONCEPTS 98 INTRODUCTION 99 HISTORY 99 THE DISEASES THE CAUSATIVE AGENTS 106 THE IMMUNE RESPONSE DIAGNOSIS 110 TREATMENT 111 PREVENTION 111 SURVEILLANCE CHAPTER 6: GROUP A STREPTOCOCCI MAJOR CONCEPTS 118 INTRODUCTION 119 HISTORY 120 THE DISEASES THE CAUSATIVE AGENTS 127 THE IMMUNE RESPONSE DIAGNOSIS 132 TREATMENT 133 PREVENTION 134 SURVEILLANCE CHAPTER 7: ESCHERICHIA COLI O157:H7 MAJOR CONCEPTS 140 INTRODUCTION 141 HISTORY 142 THE DISEASES THE CAUSATIVE AGENTS 145 THE IMMUNE RESPONSE DIAGNOSIS 152 TREATMENT 153 PREVENTION 153 SURVEILLANCE CHAPTER 8: HELICOBACTER PYLORI, ULCERS, AND CANCER MAJOR CONCEPTS 162 INTRODUCTION 163 HISTORY 164 THE DISEASES THE CAUSATIVE AGENT 168 THE IMMUNE RESPONSE DIAGNOSIS 172 TREATMENT 173 PREVENTION 174 SURVEILLANCE CHAPTER 9: LEGIONNAIRES’ DISEASE AND PONTIAC FEVER MAJOR CONCEPTS 182 INTRODUCTION 183 HISTORY 184 THE DISEASES THE CAUSATIVE AGENT 186 THE IMMUNE RESPONSE DIAGNOSIS 194 TREATMENT 197 PREVENTION 197 SURVEILLANCE CHAPTER 10: PULMONARY TUBERCULOSIS AND MULTIDRUG RESISTANCE MAJOR CONCEPTS 206 INTRODUCTION 207 HISTORY 208 THE DISEASE THE CAUSATIVE AGENTS 212 THE IMMUNE RESPONSE 213 DETECTION AND DIAGNOSIS 214 TREATMENT AND DRUG RESISTANCE 216 PREVENTION SURVEILLANCE CHAPTER 11: EMERGING BACTERIAL DRUG RESISTANCE MAJOR CONCEPTS 226 INTRODUCTION 227 HISTORY 228 THE DISEASES, CAUSATIVE AGENTS, AND TREATMENT OPTIONS 229 MECHANISMS OF RESISTANCE 235 DIAGNOSIS 239 PREVENTION 240 SURVEILLANCE PART 3: VIRAL INFECTIONS CHAPTER 12: MARBURG AND EBOLA HEMORRHAGIC FEVERS MAJOR CONCEPTS 248 INTRODUCTION 249 HISTORY 250 THE DISEASES THE CAUSATIVE AGENTS 257 THE IMMUNE RESPONSE 262 DIAGNOSIS TREATMENT 264 PREVENTION 264 SURVEILLANCE CHAPTER 13: AMERICAN HEMORRHAGIC FEVERS MAJOR CONCEPTS 274 INTRODUCTION 275 HISTORY 277 THE DISEASES THE CAUSATIVE AGENTS 282 THE IMMUNE RESPONSE 285 DIAGNOSIS TREATMENT 287 PREVENTION 287 SURVEILLANCE V CHAPTER 14: LASSA HEMORRHAGIC FEVER MAJOR CONCEPTS 294 INTRODUCTION 295 HISTORY 296 THE DISEASE THE CAUSATIVE AGENT 300 THE IMMUNE RESPONSE 303 DIAGNOSIS TREATMENT 304 PREVENTION 306 SURVEILLANCE CHAPTER 15: DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER MAJOR CONCEPTS 314 INTRODUCTION 315 HISTORY 316 THE DISEASES THE CAUSATIVE AGENT 321 THE IMMUNE RESPONSE 324 DIAGNOSIS TREATMENT 327 PREVENTION 328 SURVEILLANCE CHAPTER 16: THE HUMAN IMMUNODE? CIENCY VIRUS AND ACQUIRED IMMUNE DE? CIENCY SYNDROME MAJOR CONCEPTS 336 INTRODUCTION 338 HISTORY 339 THE DISEASES THE CAUSATIVE AGENT 344 THE IMMUNE RESPONSE 350 DIAGNOSIS AND DETECTION 355 TREATMENT 355 PREVENTION 357 SURVEILLANCE CHAPTER 17: HUMAN HERPESVIRUS 8 AND KAPOSI’S SARCOMA MAJOR CONCEPTS 366 INTRODUCTION 367 HISTORY 368 THE DISEASES THE CAUSATIVE AGENT 373 THE IMMUNE RESPONSE 378 DIAGNOSIS TREATMENT 380 PREVENTION 383 SURVEILLANCE CHAPTER 18: HEPATITIS C MAJOR CONCEPTS 390 INTRODUCTION 391 HISTORY 392 THE DISEASES THE CAUSATIVE AGENT 397 THE IMMUNE RESPONSE 399 DIAGNOSIS TREATMENT 402 PREVENTION 403 SURVEILLANCE CHAPTER 19: EPIDEMIC AND PANDEMIC IN? UENZA MAJOR CONCEPTS 410 INTRODUCTION 411 HISTORY 412 THE DISEASE THE CAUSATIVE AGENT 415 THE IMMUNE RESPONSE 421 DIAGNOSIS TREATMENT 422 PREVENTION 422 SURVEILLANCE CHAPTER 20: HANTAVIRUS PULMONARY SYNDROME MAJOR CONCEPTS 432 INTRODUCTION 433 HISTORY 435 THE DISEASES THE CAUSATIVE AGENTS 439 THE IMMUNE RESPONSE 444 DIAGNOSIS TREATMENT 446 PREVENTION 447 SURVEILLANCE CHAPTER 21: SEVERE ACUTE RESPIRATORY SYNDROME MAJOR CONCEPTS 456 INTRODUCTION 457 HISTORY 457 THE DISEASE THE CAUSATIVE AGENT 461 THE IMMUNE RESPONSE 464 DIAGNOSIS TREATMENT 466 PREVENTION 467 SURVEILLANCE CHAPTER 22: WEST NILE DISEASE IN THE UNITED STATES MAJOR CONCEPTS 476 INTRODUCTION 477 HISTORY 477 THE DISEASES THE CAUSATIVE AGENT 484 THE IMMUNE RESPONSE 487 DIAGNOSIS TREATMENT 489 PREVENTION 490 SURVEILLANCE CHAPTER 23: MONKEYPOX MAJOR CONCEPTS 500 INTRODUCTION 501 HISTORY 502 THE DISEASE THE CAUSATIVE AGENT 508 THE IMMUNE RESPONSE 511 DIAGNOSIS TREATMENT 514 PREVENTION 514 SURVEILLANCE VI PART 4: PARASITIC INFECTIONS CHAPTER 24: MALARIA: REEMERGENCE AND RECENT SUCCESSES MAJOR CONCEPTS 524 INTRODUCTION 526 HISTORY 526 THE DISEASE 528 THE CAUSATIVE AGENTS 529 THE IMMUNE RESPONSE 533 DIAGNOSIS 535 TREATMENT AND DRUG RESISTANCE PREVENTION: FAILURES AND SUCCESSES 537 SURVEILLANCE CHAPTER 25: BABESIOSIS MAJOR CONCEPTS 548 INTRODUCTION 549 HISTORY 549 THE DISEASE THE CAUSATIVE AGENT 553 THE IMMUNE RESPONSE 557 DIAGNOSIS TREATMENT 558 PREVENTION 560 SURVEILLANCE CHAPTER 26: CRYPTOSPORIDIOSIS MAJOR CONCEPTS 566 INTRODUCTION 567 HISTORY 568 THE DISEASE THE CAUSATIVE AGENTS 570 THE IMMUNE RESPONSE 576 DIAGNOSIS TREATMENT 578 PREVENTION 580 SURVEILLANCE CHAPTER 27: CHAGAS’ DISEASE AND ITS EMERGENCE IN THE UNITED STATES MAJOR CONCEPTS 586 INTRODUCTION 587 HISTORY 587 THE DISEASE THE CAUSATIVE AGENT 591 THE IMMUNE RESPONSE 595 DIAGNOSIS TREATMENT 599 PREVENTION 600 SURVEILLANCE PART 5: INFECTIOUS PROTEINS CHAPTER 28: CREUTZFELDT-JAKOB DISEASE AND OTHER TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES MAJOR CONCEPTS 610 INTRODUCTION 611 HISTORY 612 THE DISEASES THE CAUSATIVE AGENTS 621 THE IMMUNE RESPONSE 625 DIAGNOSIS TREATMENT 627 PREVENTION 628 SURVEILLANCE PART 6: SPECIAL ISSUES IN INFECTIOUS DISEASES CHAPTER 29: THE EMERGING IMPORTANCE OF INFECTIOUS DISEASES IN THE IMMUNOSUPPRESSED MAJOR CONCEPTS 636 INTRODUCTION 637 IMMUNOSUPPRESSED POPULATIONS 637 SELECTED CAUSES OF IMMUNOSUPPRESSION 638 INFECTIOUS DISEASES OF THE IMMUNOSUPPRESSED CHAPTER 30: THE EMERGING THREAT OF BIOWEAPONS MAJOR CONCEPTS 668 INTRODUCTION 669 HISTORY 670 BIOTERRORISM AGENTS AND DISEASES 671 THE THREAT OF AGROTERRORISM 692 PREPARATION FOR BIOLOGICAL ATTACKS 693 PROTECTIVE VACCINES