RADIATION DOSIMETRY

By SUSAN JACKSON

IMPLEMENTATION OF THE INTERNAL DOSE ASSESSMENT METHODS USING MODELS AND MEASUREMENTS TO DERIVE INTAKES USING MODELS TO DERIVE INTAKE RETENTION FRACTIONS DERIVING THE INTAKE FROM DATA AND MODEL-DERIVED INTAKE RETENTION FRACTIONS ASSESSMENT OF DOSES IN THE OCCUPATIONAL, ENVIRONMENTAL AND MEDICAL SETTINGS OCCUPATIONAL EXPOSURES 33211 UNSPECIFIED INDIVIDUALS 33212 SPECIFIC INDIVIDUALS ENVIRONMENTAL EXPOSURES 33221 UNSPECIFIED INDIVIDUALS 33222 SPECIFIC INDIVIDUALS MEDICAL EXPOSURES 33231 UNSPECIFIED INDIVIDUALS 33232 SPECIFIC INDIVIDUALS 33233 DOSIMETRY METHODOLOGY FOR PRECLINICAL STUDIES 4 SOURCES, TYPES AND CATEGORIES OF UNCERTAINTIES INTRODUCTION SOURCES OF UNCERTAINTY IN INTERNAL DOSIMETRY UNCERTAINTIES IN MEASUREMENTS UNCERTAINTIES IN BIOASSAY MEASUREMENTS UNCERTAINTIES IN ENVIRONMENTAL MEASUREMENTS SOURCES OF UNCERTAINTY RELATED TO THE CHARACTERISTICS OF THE INTAKE UNCERTAINTIES RELATED TO PERSONAL INFORMATION UNCERTAINTIES RELATED TO AN UNKNOWN ROUTE OF INTAKE UNCERTAINTIES RELATED TO AN UNKNOWN PHYSICAL FORM, CHEMICAL FORM, OR ISOTOPIC COMPOSITION OF AN ELEMENT UNCERTAINTIES ASSOCIATED WITH AN UNKNOWN TIME OF INTAKE MISSED AND UNMONITORED INTERNAL DOSES UNCERTAINTIES IN OTHER INITIAL CONDITIONS ESTIMATING HEIGHT WITH A UNIFORM PRIOR BRIEF INTRODUCTION TO THE MCMC METHOD METHODS FOR OBTAINING PRIOR DISTRIBUTIONS USING EMPIRICAL BAYES’ METHODS METHODS FOR OBTAINING PRIOR DISTRIBUTIONS USING SUBJECTIVE INFORMATION 53321 GENERAL PRINCIPLES: INDIFFERENCE, INVARIANCE AND MAXIMUM ENTROPY 53322 EXPERT ELICITATION BAYESIAN HYPOTHESIS TESTING ADVANTAGES AND CRITICISMS OF THE BAYESIAN APPROACH ADVANTAGES 53511 NATURALNESS 53512 RATIONALITY 53513 INCORPORATION OF SUBJECTIVE INFORMATION AND WORKING WITHOUT DATA CRITICISMS 53521 DOMINATION BY THE PRIOR 53522 ZERO PRESERVATION 53523 SPECIFYING THE PRIOR 53524 SUBJECTIVITY 53525 STRUCTURAL OMNISCIENCE CLASSICAL METHODS FORMULATION OF THE PROBLEM POSSIBLE SOLUTIONS TO THE PROBLEM MAXIMUM-LIKELIHOOD METHOD LEAST-SQUARES METHOD APPLICATION OF THE MAXIMUM-LIKELIHOOD METHOD TO AN EXAMPLE OF IODINE INTAKE CLASSICAL DECISION LEVELS A BAYESIAN APPROACH (WEIGHTED LIKELIHOOD MONTE-CARLO SAMPLING) WHICH HAS EVOLVED FROM A CLASSIC MONTE- CARLO APPROACH CLASSIC MONTE-CARLO APPROACH EXAMPLE 1: RADON DOSIMETRY EXAMPLE 2: TRITIUM MONITORING EXAMPLE 3: EXPOSURE TO DEPLETED URANIUM WELMOS METHOD APPLICATIONS OF THE WELMOS METHOD COMPARISON OF STATISTICAL METHODS AND NUMERICAL TECHNIQUES BLOOD METHOD IMAGING METHOD UNCERTAINTY IN ORGAN-MASS DETERMINATION BY CT VOLUMETRY 7 UNCERTAINTIES IN THE INTAKES INHALATION INGESTION ABSORPTION THROUGH INTACT OR DAMAGED SKIN INTRAVENOUS ADMINISTRATION 8 UNCERTAINTIES IN THE STRUCTURE AND PARAMETERS OF THE BIOKINETIC AND DOSIMETRIC MODELS ICRP HUMAN RESPIRATORY TRACT MODEL DESCRIPTION OF THE MODEL SUMMARY OF UNCERTAINTIES IN HRTM COMPONENTS ICRP HUMAN ALIMENTARY TRACT MODEL BACKGROUND OVERVIEW OF THE UPDATED MODEL (HATM) UNCERTAINTIES IN FEATURES AND PREDICTIONS OF HATM ELEMENT-INDEPENDENT SOURCES OF UNCERTAINTY IN HATM GASTROINTESTINAL ABSORPTION FRACTIONS WOUND AND ABSORPTION THROUGH INTACT SKIN NCRP WOUND MODEL UNCERTAINTY IN NCRP WOUND-MODEL PREDICTIONS UNCERTAINTY IN THE WOUND-MODEL STRUCTURE UNCERTAINTY IN THE WOUND-MODEL PARAMETERS TRANSDERMAL ABSORPTION SYSTEMIC MODELS OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES STRONTIUM 85111 SUMMARY OF THE BIOKINETIC DATABASE 85112 CORRELATIONS AMONG SYSTEMIC PARAMETERS IODINE CARBON DIOXIDE 85153 SUMMARY OF UNCERTAINTIES IN BIOKINETICS AND DOSIMETRY FOR LONG-LIVED URANIUM ISOTOPES CONTENTS 85182 ICRP MODEL FOR SYSTEMIC RUTHENIUM 85183 SUMMARY OF UNCERTAINTIES IN BIOKINETICS AND DOSIMETRY ESTIMATES FOR 106RU RADON GAS AND ITS PROGENY CONSIDERATIONS FOR RADIOPHARMACEUTICALS