THE PHYSICS OF VIRUSES
CONTENTS PART I THE VIRAL MACHINE INTRODUCTION: THE STRUCTURAL BASIS OF VIRUS FUNCTION THE BASIC ARCHITECTURE OF VIRUSES PART II DETERMINATION OF THE STRUCTURE AND PHYSICAL PROPERTIES OF VIRUSES CONVENTIONAL ELECTRON MICROSCOPY, CRYO-ELECTRON MICROSCOPY AND CRYO-ELECTRON TOMOGRAPHY OF VIRUSES X-RAY CRYSTALLOGRAPHY OF VIRUSES NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY TO STUDY VIRUS STRUCTURE FLUORESCENCE, CIRCULAR DICHROISM AND MASS SPECTROMETRY AS TOOLS TO STUDY VIRUS STRUCTURE COMBINED APPROACHES TO STUDY VIRUS STRUCTURES ATOMIC FORCE MICROSCOPY OF VIRUSES OPTICAL TWEEZERS TO STUDY VIRUSES PART III STRUCTURAL FOUNDATIONS OF VIRUS PROPERTIES AND FUNCTIONS ASSEMBLY OF SIMPLE ICOSAHEDRAL VIRUSES STRUCTURE AND ASSEMBLY OF COMPLEX VIRUSES NUCLEIC ACID PACKAGING IN VIRUSES VIRUS MATURATION VIRUS MORPHOGENESIS IN THE CELL: METHODS AND OBSERVATIONS CRISTINA RISCO AND ISABEL FERNA´NDEZ DE CASTRO VIRUS-RECEPTOR INTERACTIONS AND RECEPTOR-MEDIATED VIRUS ENTRY INTO HOST CELLS ENTRY OF ENVELOPED VIRUSES INTO HOST CELLS: MEMBRANE FUSION BACTERIOPHAGE RECEPTOR RECOGNITION AND NUCLEIC ACID TRANSFER MECHANICAL PROPERTIES OF VIRUSES THEORETICAL STUDIES ON ASSEMBLY, PHYSICAL STABILITY AND DYNAMICS OF VIRUSES PART IV APPLIED STRUCTURAL AND PHYSICAL VIROLOGY ANTIVIRAL AGENTS: STRUCTURAL BASIS OF ACTION AND RATIONAL DESIGN DESIGN OF NOVEL VACCINES BASED ON VIRUS-LIKE PARTICLES OR CHIMERIC VIRIONS NANOSCALE SCIENCE AND TECHNOLOGY WITH PLANT VIRUSES AND BACTERIOPHAGES