DRUG TRANSPORTER: MOLECULAR CHARACTERIZATION AND ROLE IN DRUG DISPOSITION

By X. CANAA

1 OVERVIEW OF DRUG TRANSPORTER FAMILIES 2 ORGANIC CATION TRANSPORTERS 3 ORGANIC CATION/CARNITINE TRANSPORTERS 4 ORGANIC ANION TRANSPORTERS 5 ORGANIC ANION–TRANSPORTING POLYPEPTIDES 6 MAMMALIAN OLIGOPEPTIDE TRANSPORTERS 7 MONOCARBOXYLATE TRANSPORTERS 8 NUCLEOSIDE TRANSPORTERS: CNTS AND ENTS 9 BILE ACID TRANSPORTERS 10 MULTIDRUG RESISTANCE PROTEIN: P-GLYCOPROTEIN 11 MULTIDRUG RESISTANCE PROTEINS OF THE ABCC SUBFAMILY 12 BREAST CANCER RESISTANCE PROTEIN 13 DRUG TRANSPORT IN THE LIVER 14 DRUG TRANSPORT IN THE BRAIN 15 DRUG TRANSPORT IN THE KIDNEY 16 DRUG TRANSPORTERS IN THE INTESTINE 17 REGULATION OF DRUG TRANSPORTER ACTIVITY 18 EXPERIMENTAL APPROACHES TO THE STUDY OF DRUG TRANSPORTERS 19 IN VITRO–IN VIVO SCALE-UP OF DRUG TRANSPORT ACTIVITIES 20 AGE- AND GENDER-RELATED DIFFERENCES IN XENOBIOTIC TRANSPORTER EXPRESSION 21 POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE 22 DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS 23 INTERPLAY OF DRUG TRANSPORTERS AND ENZYMES ON HEPATIC DRUG PROCESSING 24 CLINICAL RELEVANCE: DRUG–DRUG INTERACTIONS,