POISONS: THEIR ISOLATION AND IDENTIFICATION

By RICHARD THOMPSON

CONTENTS SECTION I POISON POISON AND POISONING INTRODUCTION POISONS POTENCY MECHANISMS POISONING RECOGNITION MORBIDITY AND MORTALITY IN CONTEXT CASE STUDIES REFERENCES AND ADDITIONAL READING POISON EXPOSURE DOSE BLOOD LEVELS KINETICS MULTIPLE SUBSTANCE EXPOSURES CNS DEPRESSANTS SEROTONERGIC AGENTS AGENTS THAT PRODUCE QT PROLONGATION EFFECTS ON MULTIPLE ORGAN SYSTEMS PHARMACOKINETIC INTERACTIONS CONTENTS POISON ABSORPTION ROUTES OF ADMINISTRATION AND DOSAGE FORMS UTILIZED IN CLINICAL MEDICINE ORAL RECTAL VAGINAL NASAL TRANSDERMAL INJECTION INHALATION ROUTES OF ADMINISTRATION UNIQUE TO SUBSTANCE ABUSE SNORTING AND INJECTING POWDERED TABLETS TRANSDERMAL PATCHES SMOKING FAD METHODS OF SUBSTANCE ABUSE ABSORPTION FROM BODY CAVITIES INTENTIONAL POISONING POISON BIODISPOSITION METABOLISM EXCRETION POSTMORTEM REDISTRIBUTION POISON DETECTION ANTEMORTEM TOXICOLOGY POSTMORTEM TOXICOLOGY FORENSIC CHEMICAL ANALYSIS POISONING TREATMENT ASSESSMENT PATIENT HISTORY CLINICAL AND MEDICAL LABORATORY EVALUATION TOXIDROMES TOXICOLOGY TESTING TREATMENT LIFE SUPPORT SYMPTOMATIC AND SUPPORTIVE CARE ANTIDOTES EVIDENCE-BASED TREATMENT GUIDELINES REMOVING INGESTED SUBSTANCES AND HASTENING THEIR ELIMINATION GASTRIC REMOVAL HEMODIALYSIS INTRAVENOUS LIPID ADMINISTRATION SECTION II POTENTIAL POISONS ARSENIC EXPOSURE SITUATIONS AND CIRCUMSTANCES SYMPTOMS OF POISONING CARBON MONOXIDE CYANIDE ETHYLENE GLYCOL NICOTINE STRYCHNINE THALLIUM ASPIRIN ACETAMINOPHEN ALCOHOL ABSORPTION EXPOSURE OPIOIDS ANTIDEPRESSANTS BENZODIAZEPINES STIMULANTS EMERGING RECREATIONAL PSYCHOTROPICS SYMPTOMS OF TOXICITY FOOD POISONING INVESTIGATIVE CONSIDERATIONS PLANTS AND MUSHROOMS ANGEL’S TRUMPET (BRUGMANSIA SUAVEOLENS) CASTOR BEAN PLANT (RICINUS COMMUNIS) DEADLY NIGHTSHADE (ATROPA BELLADONNA) GLORY LILY (GLORIOSA SUPERBA) FOXGLOVE (DIGITALIS PURPUREA) POISON HEMLOCK (CONIUM MACULATUM) WATER HEMLOCK (CICUTA DOUGLASII) MONKSHOOD (ACONITUM NAPELLUS) OLEANDER (NERIUM OLEANDER) ROSARY PEA (ABRUS PRECHTORIUS) MUSHROOMS PESTICIDES SECTION III POISONING ACCIDENTAL POISONING PEDIATRIC POISONING THERAPEUTIC MISADVENTURES DRUG COMBINATIONS NONTOXIC INGESTIONS CHILDREN LIVING WITH SUBSTANCE ABUSERS SUICIDAL POISONING IMPULSIVITY INTERNET PSYCHOTHERAPEUTIC MEDICATION PSYCHOLOGICAL AUTOPSY STAGING DEATH SCENE HOMICIDAL POISONING POISONERS DEATH INVESTIGATION POISONOUS WOMEN HEALTH CARE SERIAL POISONERS HOSPITALIZED PATIENTS POISONED BY VISITORS MEDICAL CHILD ABUSE AND HOMICIDE DRUG ABUSE FATALITIES SYMPTOMS SUBSTANCES ETHANOL COCAINE BARBITURATES AMPHETAMINES HALLUCINOGENS INHALANTS EMERGING SYNTHETIC PSYCHOTROPIC SUBSTANCES CELEBRITY DRUG DEATHS DRUG-FACILITATED CRIMES ROBBERY SUBLETHAL POISONING TERMINATION OF PREGNANCY SEDATION BY CAREGIVERS SPORTING ADVANTAGE COMMERCIAL ADVANTAGE INTERROGATION DRUG-FACILITATED SEXUAL ASSAULT PURPORTED APHRODISIACS DRUG PRODUCT TAMPERING ASSASSINATION MULTIPLE VICTIM POISONINGS INDUSTRIAL CHEMICALS TERRORISM MASS SUICIDE RECREATIONAL DRUGS