VETERINARY MATERIA MEDICA AND THERAPEUTICS
Section I: Amino Acid and Protein Metabolism Chapter 1 Chemical Composition of Living Cells 2 2 Properties of Amino Acids 7 3 Amino Acid Modifications 12 4 Protein Structure 18 5 Properties of Enzymes 24 6 Enzyme Kinetics 30 7 Protein Digestion 36 8 Amino Acid Catabolism 42 9 Transamination and Deamination Reactions 49 10 Urea Cycle (Krebs-Henseleit Ornithine Cycle) 55 11 Glutamine and Ammonia 61 12 Nonprotein Derivatives of Amino Acids 66 Section II: Nucleotide and Nucleic Acid Metabolism Chapter 13 Nucleotides 74 14 Pyrimidine Biosynthesis 79 15 Purine Biosynthesis 84 16 Folic Acid 89 17 Nucleic Acid and Nucleotide Turnover 94 Section III: Carbohydrate and Heme Metabolism Chapter 18 Carbohydrate Structure 102 19 Polysaccharides and Carbohydrate Derivatives 108 20 Glycoproteins and Glycolipids 114 21 Overview of Carbohydrate Metabolism 120 22 Glucose Trapping 125 23 Glycogen 131 24 Introduction to Glycolysis (The Embden-Meyerhoff Pathway (EMP)) 137 25 Initial Reactions in Anaerobic Glycolysis 142 26 Intermediate Reactions in Anaerobic Glycolysis 147 27 Metabolic Fates of Pyruvate 152 28 Hexose Monophosphate Shunt (HMS) 157 29 Uronic Acid Pathway 162 30 Erythrocytic Protection from O2 Toxicity 167 31 Carbohydrate Metabolism in Erythrocytes 172 32 Heme Biosynthesis 177 33 Heme Degradation 183 34 Tricarboxylic Acid (TCA) Cycle 189 35 Leaks in the Tricarboxylic Acid (TCA) Cycle 194 36 Oxidative Phosphorylation 199 37 Gluconeogenesis 205 38 Carbohydrate Digestion 211 Section IV: Vitamins and Trace Elements Chapter 39 Vitamin C 220 40 Thiamin (B1) and Riboflavin (B2) 226 41 Niacin (B3) and Pantothenic Acid (B5) 231 42 Biotin and Pyridoxine (B6) 237 43 Cobalamin (B12) 242 44 Vitamin A 248 45 Vitamin D 254 46 Vitamin E 260 47 Vitamin K 265 48 Iron 270 49 Zinc 275 50 Copper 280 51 Manganese and Selenium 285 52 Iodine and Cobalt 291 Section V: Lipid Metabolism Chapter 53 Overview of Lipid Metabolism 298 54 Saturated and Unsaturated Fatty Acids 303 55 Fatty Acid Oxidation 309 56 Fatty Acid Biosynthesis 315 57 Triglycerides and Glycerophospholipids 321 58 Phospholipid Degradation 327 59 Sphingolipids 332 60 Lipid Digestion 338 61 Cholesterol 344 62 Bile Acids 350 63 Lipoprotein Complexes 356 64 Chylomicrons 361 65 VLDL, IDL, and LDL 366 66 LDL Receptors and HDL 371 67 Hyperlipidemias 377 68 Eicosanoids I 383 69 Eicosanoids II 388 70 Lipolysis 393 71 Ketone Body Formation and Utilization 399 72 Fatty Liver Syndrome (Steatosis) 405 Section VI: Intermediary Metabolism Chapter 73 Starvation (Transition into the Postabsorptive Stage) 412 74 Starvation (The Early Phase) 418 75 Starvation (The Intermediate Phase) 423 76 Starvation (The Late Phase) 428 77 Exercise (Circulatory Adjustments and Creatine) 433 78 Exercise (V O2(max) and RQ) 439 79 Exercise (Substrate Utilization and Endocrine Parameters) 444 80 Exercise (Muscle Fiber Types and Characteristics) 449 81 Exercise (Athletic Animals) 455 Section VII: Acid-Base Balance Chapter 82 Hydrogen Ion Concentration 462 83 Strong and Weak Electrolytes 467 84 Protein Buffer Systems 472 85 Bicarbonate, Phosphate, and Ammonia Buffer Systems 477 86 Anion Gap 483 87 Metabolic Acidosis 489 88 Diabetes Mellitus (Metabolic Acidosis and Potassium Balance) 496 89 Metabolic Alkalosis 503 90 Respiratory Acidosis 510 91 Respiratory Alkalosis 516 92 Strong Ion Difference (SID) 522 93 Alkalinizing and Acidifying Solutions 532 94 Dehydration/Overhydration 538