Principles Of Pharmacovigilance And Drug Safety

By ROBERT HERNANDEZ

Part I Historical Aspects of Drug Discovery 1 The Great Pharmacologists and Their Revolutionary Discoveries ???????????????????????????????????????????????????????????????????????????????????????????????? 3 2 Indian Contributions to Pharmacology ???????????????????????????????????????????????? 41 Part II General Pharmacological Principles 3 Sources and Nature of Drugs ?????????????????????????????????????????????????????????????????? 61 4 Principles and Modes of Drug Administration ???????????????????????????????????? 69 5 Drug Absorption and Bioavailability ???????????????????????????????????????????????????? 81 6 Drug Distribution ???????????????????????????????????????????????????????????????????????????????????? 89 7 Drug Metabolism ???????????????????????????????????????????????????????????????????????????????????? 99 8 Drug Elimination ???????????????????????????????????????????????????????????????????????????????????? 117 9 Mechanisms of Drug Action ???????????????????????????????????????????????????????????????????? 131 10 Drug Transporters ?????????????????????????????????????????????????????????????????????????????????? 155 11 Adverse Effects and Pharmacovigilance ???????????????????????????????????????????????? 177 12 Drug Interactions ???????????????????????????????????????????????????????????????????????????????????? 197 13 Structure-Activity Relationships ???????????????????????????????????????????????????????????? 205 Part III Special Topics in Pharmacology 14 Drug Information ???????????????????????????????????????????????????????????????????????????????????? 223 15 Pharmacogenetics, Pharmacogenomics, and Personalized Medicine ???????????????????????????????????????????????????????????????????????????????????????????????????? 235 16 Chronopharmacology ?????????????????????????????????????????????????????????????????????????????? 261 17 Pharmacoepidemiology ?????????????????????????????????????????????????????????????????????????? 271 18 Ethnopharmacology ???????????????????????????????????????????????????????????????????????????????? 281 19 Pharmacoeconomics ???????????????????????????????????????????????????????????????????????????????? 297 20 Orphan Diseases and Drugs ???????????????????????????????????????????????????????????????????? 303 21 Fixed-Dose Combinations ?????????????????????????????????????????????????????????????????????? 307 22 Translational and Reverse Pharmacology ???????????????????????????????????????????? 313 23 Gene Therapy ?????????????????????????????????????????????????????????????????????????????????????????? 319 24 Stem Cell Therapy ?????????????????????????????????????????????????????????????????????????????????? 329 25 Principles of Prescription Writing ?????????????????????????????????????????????????????????? 343 Part IV Toxicology 26 Environmental Toxicology ?????????????????????????????????????????????????????????????????????? 351 27 Basic Principles of Management of Drug Poisoning ???????????????????????????? 361 Part V Molecular Biology in Pharmacology 28 Regulation of Gene Expression ?????????????????????????????????????????????????????????????? 381 29 Proteomics ???????????????????????????????????????????????????????????????????????????????????????????????? 387 30 Techniques Involved in Studying Receptor Dynamics ?????????????????????????? 391 31 Polymerase Chain Reaction ???????????????????????????????????????????????????????????????????? 395 32 Southern, Western and Northern Blotting ???????????????????????????????????????????? 399 33 Antisense Oligonucleotides ?????????????????????????????????????????????????????????????????????? 407 34 Recombinant DNA Technology ?????????????????????????????????????????????????????????????? 413