AN EPHEMERIS OF MATERIA MEDICA, PHARMACY, AND THERAPEUTICS, AND COLLATERAL INFORMATION
CONTENTS CHAPTER INTRODUCTION 1 1 MAGIC BULLETS 1 2 BACKGROUND TO MODERN PHARMACOLOGY 1 2 1 THE RECEPTOR THEORY 1 2 2 MOLECULAR PHARMACOLOGY 1 2 3 RECEPTORS, SIGNALS AND ENZYMES 1 2 4 RECOMBINANT DNA TECHNOLOGY AND TARGET DISCOVERY 1 3 DRUG AND THERAPEUTIC TARGETS IN THE BIOMEDICAL LITERATURE 1 4 HOW MANY DRUG TARGETS ARE THERE? 1 4 1 SYSTEMATIC TARGET DISCOVERY 1 5 SCREENING FOR ACTIVE MOLECULES REFERENCES CHAPTER OVERVIEW OF THE DRUG TARGET COMPENDIUM 2 1 INTRODUCTORY COMMENTS 2 2 SELECTION OF ENTRIES 2 2 1 GENE NAME AND SYMBOL 2 2 2 DRUG/INVESTIGATIONAL COMPOUND NAME 2 2 3 LITERATURE REFERENCE 2 2 4 INVOLVEMENT IN DISEASE 2 3 ORGANIZATION OF ENTRIES 2 3 1 CELL SURFACE AND SECRETED PROTEINS 2 3 2 ENZYMES 2 3 3 ENTRIES CLASSIFIED BY SUBCELLULAR LOCATION 2 3 4 NON?CODING RNAS 2 4 SUMMARY OF DATA ENTRIES 2 5 HOW TO USE THIS BOOK 2 6 FINAL COMMENTS CELL SURFACE AND SECRETED PROTEINS 3 1 G?PROTEIN?COUPLED RECEPTORS (GPCRS) 3 1 1 G?PROTEIN?COUPLED RECEPTOR (GPCR) LIGANDS 3 2 NUCLEAR HORMONE RECEPTORS (NHRS) 3 3 CYTOKINES AND RECEPTORS 3 4 ADHESION MOLECULES 3 5 HOST DEFENCE MOLECULES 3 6 TRANSPORTERS AND CHANNELS 3 6 1 ATP?BINDING CASSETTE FAMILIES AND TRANSPORTING ATPASES 3 6 2 SOLUTE CARRIER (SLC) FAMILIES 3 6 3 LIGAND?GATED ION CHANNELS 3 6 4 VOLTAGE?GATED ION CHANNELS 3 6 5 ASSORTED TRANSPORT AND CARRIER PROTEINS ENZYMES: PART 4 1 SIGNALLING ENZYMES 4 1 1 PROTEIN KINASES 4 1 2 PROTEIN PHOSPHATASES 4 1 3 CYCLIC NUCLEOTIDES AND PHOSPHODIESTERASES 4 1 4 GTPASE SIGNALLING PROTEINS 4 1 5 OTHER SIGNALLING ENZYMES 4 2 PROTEIN MODIFICATION 4 2 1 PEPTIDASES 4 2 1 1 PEPTIDASE INHIBITORS 4 2 2 GLYCOSYLATION 4 2 3 UBIQUITYLATION AND RELATED MODIFICATIONS 4 2 4 CHROMATIN MODIFICATION 4 2 5 PROTEIN SYNTHESIS AND FOLDING 4 2 6 OTHER PROTEIN MODIFICATIONS 5 1 LIPIDS AND RELATED 5 2 AMINO ACIDS AND RELATED 5 3 NUCLEOTIDES AND RELATED 5 4 CARBOHYDRATES AND RELATED 5 5 VITAMINS, COFACTORS AND RELATED 5 6 DNA?PROCESSING ENZYMES 5 7 RNA?PROCESSING ENZYMES 5 8 STRESS RESPONSE AND HOMEOSTASIS 5 9 MISCELLANEOUS ENZYMES REMAINING ANNOTATED ENTRIES GROUPED BY SUBCELLULAR LOCATION 6 1 CELL SURFACE AND SECRETED PROTEINS 6 2 CYTOSKELETON 6 3 CYTOPLASM TO NUCLEUS 6 4 NUCLEUS 6 5 INTERNAL MEMBRANES AND ORGANELLES 6 6 CYTOPLASMIC PROTEINS 6 7 SUBCELLULAR LOCATION NOT ANNOTATED NON?CODING RNAS