PHARMACEUTICAL FORMULATION DEVELOPMENT OF PEPTIDES AND PROTEINS

By MARK GONZALEZ

CONTENTS CURRENT ADVANCEMENTS IN ADDRESSING KEY CHALLENGES OF THERAPEUTIC ANTIBODY DESIGN, MANUFACTURE, AND FORMULATION ANTIBODY CONJUGATES-RECENT ADVANCES AND FUTURE INNOVATIONS DISCOVERY STRATEGIES TO MAXIMIZE THE CLINICAL POTENTIAL OF T-CELL ENGAGING ANTIBODIES FOR THE TREATMENT OF SOLID TUMORS MONOCLONAL ANTIBODIES FOR SUBCUTANEOUS ADMINISTRATION ANTIBODIES INHIBITING THE TYPE III SECRETION SYSTEM OF GRAM-NEGATIVE PATHOGENIC BACTERIA PRINCIPLES OF N-LINKED GLYCOSYLATION VARIATIONS OF IGG-BASED THERAPEUTICS: PHARMACOKINETIC AND FUNCTIONAL CONSIDERATIONS