CHIRALITY IN DRUG DESIGN AND DEVELOPMENT

By F. RAKAY

CONTENTS 1 E?ECTS OF CRYSTAL STRUCTURE AND PHYSICAL PROPERTIES ON THE RELEASE OF CHIRAL DRUGS 2 USE OF CHIRAL EXCIPIENTS IN FORMULATIONS CONTAINING CHIRAL DRUGS 3 TRANSPORT OF CHIRAL MOLECULES ACROSS THE SKIN 4 STEREOSELECTIVE DRUG DELIVERY THROUGH PRODRUG APPROACH 5 STEREOSELECTIVITY IN DRUG ACTION AND DISPOSITION: AN OVERVIEW 6 STEREOSPECI?C PHARMACOKINETICS AND PHARMACODYNAMICS: SELECTED CLASSES OF DRUGS 7 STEREOSPECI?C PHARMACOKINETICS AND PHARMACODYNAMICS: CARDIOVASCULAR DRUGS 8 CHIRAL INVERSION 9 BIOEQUIVALENCY DETERMINATION OF RACEMIC DRUG FORMULATIONS: IS STEREOSPECI?C ASSAY ESSENTIAL? 10 REGULATORY CONSIDERATIONS IN DRUG DEVELOPMENT OF STEREOISOMERS X CONTENTS