THERAPEUTICS, MATERIA MEDICA AND PHARMACY

By SUSAN HARRIS

CONTENTS 1 THE HERITAGE OF PHARMACOLOGY 2 THE SCOPE OF PHARMACOLOGY 3 HOW DRUGS ACT ON THE LIVING ORGANISM 4 HOW DRUGS REACH THEIR SITE OF ACTION I GENERAL PRINCIPLES OF PASSAGE OF DRUGS ACROSS BIOLOGIC BARRIERS 5 HOW DRUGS REACH THEIR SITE OF ACTION II ABSORPTION 6 HOW DRUGS REACH THEIR SITE OF ACTION III DISTRIBUTION 7 HOW THE ACTIONS OF DRUGS ARE TERMINATED I EXCRETION 8 HOW THE ACTIONS OF DRUGS ARE TERMINATED II BIOTRANSFORMATION 9 GENERAL PRINCIPLES OF THE QUANTITATIVE ASPECTS OF DRUG ACTION I DOSE-RESPONSE RELATIONSHIPS 10 GENERAL PRINCIPLES OF THE QUANTITATIVE ASPECTS OF DRUG ACTION II TIME-RESPONSE RELATIONSHIPS 11 FACTORS MODIFYING THE EFFECTS OF DRUGS IN INDIVIDUALS I VARIABILITY IN RESPONSE ATTRIBUTABLE TO THE BIOLOGIC SYSTEM 12 FACTORS MODIFYING THE EFFECTS OF DRUGS IN INDIVIDUALS II VARIABILITY IN RESPONSE ATTRIBUTABLE TO THE CONDITIONS OF ADMINISTRATION 13 DRUG TOXICITY 14 HOW DRUGS ALTER PHYSIOLOGIC FUNCTION 15 THE PHARMACOLOGIC ASPECTS OF DRUG ABUSE 16 THE DEVELOPMENT AND EVALUATION OF NEW DRUGS