SECRETASES
CONTENTS 1 MEMBRANE TYPE-MATRIX METALLOPROTEINASES (MT-MMP) I INTRODUCTION II SECRETED MMPS III MEMBRANE TYPE-MATRIX METALLOPROTEINASES (MT-MMPS) IV SUMMARY AND CONCLUDING REMARKS REFERENCES 2 SURFACE ASSOCIATION OF SECRETED MATRIX METALLOPROTEINASES I INTRODUCTION III SURFACE BINDING OF THE SOLUBLE INTERSTITIAL COLLAGENASES (MMP-1 AND MMP-13) VI CONCLUDING REMARKS SURFACE BINDING: A BALANCE BETWEEN POSITIVE AND NEGATIVE EFFECTS ON PERICELLULAR PROTEOLYSIS 3 BIOCHEMICAL PROPERTIES AND FUNCTIONS OF MEMBRANE-ANCHORED METALLOPROTEASE-DISINTEGRIN PROTEINS (ADAMS) I INTRODUCTION II STRUCTURAL CHEMISTRY AND BIOCHEMISTRY III EXPRESSION IN DIFFERENT TISSUES AND REGULATION OF GENE EXPRESSION IV INTERACTIONS OF ADAMS WITH OTHER EXTRACELLULAR AND INTRACELLULAR PROTEINS V ROLES IN EMBRYOGENESIS AND DEVELOPMENT VI ROLES IN DISEASE VII CONCLUDING COMMENTS AND FUTURE DIRECTIONS 4 SHEDDING OF PLASMA MEMBRANE PROTEINS I INTRODUCTION II FUNCTIONAL CONSEQUENCES OF ECTODOMAIN SHEDDING III PROTEASES INVOLVED IN ECTODOMAIN SHEDDING IV HOW ARE SUBSTRATES SELECTED? V REGULATION 5 EXPRESSION OF MEPRINS IN HEALTH AND DISEASE I INTRODUCTION II EXPRESSION AND PROPOSED FUNCTIONS OF ASTACIN FAMILY MEMBERS III MEPRIN EXPRESSION IN CANCER IV MEPRINS IN IN?AMMATORY DISEASES V SUMMARY, CONCLUDING REMARKS, FUTURE DIRECTIONS 6 TYPE II TRANSMEMBRANE SERINE PROTEASES I INTRODUCTION II GENERAL FEATURES OF TYPE II TRANSMEMBRANE SERINE PROTEASES III CORIN IV ENTEROPEPTIDASE V HEPSIN VI MATRIPTASE VII TRANSMEMBRANE PROTEASE, SERINE 2 (TMPRSS2) VIII TRANSMEMBRANE PROTEASE, SERINE 3 (TMPRSS3) IX TRANSMEMBRANE PROTEASE, SERINE 4 (TMPRSS4) X OTHER TRANSMEMBRANE SERINE PROTEASES XI PERSPECTIVE DPPIV, SEPRASE, AND RELATED SERINE PEPTIDASES IN MULTIPLE CELLULAR FUNCTIONS I INTRODUCTION II STRUCTURAL CHEMISTRY AND BIOCHEMISTRY OF SIMP III BIOLOGIC AND PATHOLOGIC ROLES IV CONCLUSIONS AND FUTURE DIRECTIONS THE SECRETASES OF ALZHEIMER’S DISEASE I THE AMYLOID HYPOTHESIS OF ALZHEIMER’S DISEASE II ?-SECRETASE III ? -SECRETASE IV ?-SECRETASE V CONCLUDING REMARKS 9 PLASMINOGEN ACTIVATION AT THE CELL SURFACE I INTRODUCTION II STRUCTURAL CHEMISTRY/BIOCHEMISTRY III CELLULAR BINDING SITES AND THE REGULATION OF THE PLASMINOGEN ACTIVATION SYSTEM IV UPAR AS A REGULATOR OF CELL MIGRATION V BIOLOGICAL AND PATHOLOGICAL ROLES VI CONCLUDING REMARKS 10 CELL-SURFACE CATHEPSIN B: UNDERSTANDING ITS FUNCTIONAL SIGNI?CANCE I INTRODUCTION II CATHEPSIN B EXPRESSION AND CANCER III COMPARTMENTALIZATION OF CATHEPSIN B IV ASSOCIATION OF CATHEPSIN B WITH THE CELL SURFACE V FUNCTIONAL SIGNI?CANCE OF CELL-SURFACE CATHEPSIN B VI CONCLUSIONS