CELLULAR BASIS OF CHEMICAL MESSENGERS IN THE DIGESTIVE SYSTEM
CONTENTS INTRODUCTION MOLECULAR AND CELLULAR FUNCTIONS OF CTLA-4 ROLES OF PD-1/PD-L1 PATHWAY: SIGNALING, CANCER, AND BEYOND DISCOVERY OF NEW IMMUNE CHECKPOINTS: FAMILY GROWS UP MECHANISMS OF RESISTANCE TO CHECKPOINT BLOCKADE THERAPY MOLECULAR EVENTS BEHIND ADVERSE EFFECTS RATIONAL DISCOVERY OF RESPONSE BIOMARKERS: CANDIDATE PROGNOSTIC FACTORS AND BIOMARKERS FOR CHECKPOINT INHIBITOR-BASED IMMUNOTHERAPY SPATIOTEMPORAL CHANGES IN CHECKPOINT MOLECULE EXPRESSION FUNCTIONS OF IMMUNE CHECKPOINT MOLECULES BEYOND IMMUNE EVASION GENETIC ALTERATIONS AND CHECKPOINT EXPRESSION: MECHANISMS AND MODELS FOR DRUG DISCOVERY REGULATIONS ON MESSENGER RNA: WIRES AND NODES FOLDED OR DEGRADED IN ENDOPLASMIC RETICULUM REGULATION OF CANCER IMMUNE CHECKPOINT: MONO- AND POLY-UBIQUITINATION: TAGS FOR FATE LYSOSOME AS THE BLACK HOLE FOR CHECKPOINT MOLECULES PHOSPHORYLATION: A FAST SWITCH FOR CHECKPOINT SIGNALING PALMITOYLATION AS A SIGNAL FOR DELIVERY METHODOLOGY FOR DETECTING PROTEIN PALMITOYLATION CHECKPOINTS UNDER TRAF?C CONTROL: FROM AND TO ORGANELLES EXOSOME AND SECRETION: ACTION ON? MACROMOLECULES AND ANTIBODY-BASED DRUGS MECHANISMS INSPIRED TARGETING PEPTIDES SMALL MOLECULAR IMMUNE MODULATORS AS ANTICANCER AGENTS THERAPEUTIC DEVELOPMENT OF IMMUNE CHECKPOINT INHIBITORS CONCLUDING REMARKS