THE CANCER HANDBOOK

By DONALD CLARK

PART I: BASIC SCIENCE OF TUMOR ANTIGENS AND IMMUNE ACTIVATION BIOLOGY OF THE CANCER VACCINE IMMUNE RESPONSE THE RATIONAL DESIGN OF T-CELL EPITOPES WITH ENHANCED IMMUNOGENICITY IDENTIFICATION OF TUMOR ANTIGENS USING SUBTRACTION AND MICROARRAYS TUMOR ANTIGEN DISCOVERY WITH T CELLS TARGETING VIRAL ANTIGENS FOR THE TREATMENT OF MALIGNANCIES IMMUNE DEFECTS IN CANCER ESCAPE OF TUMORS FROM THE IMMUNE SYSTEM: ROLE OF THE TRANSFORMING GROWTH FACTOR-?-SIGNALING PATHWAY PART II: GENERAL VACCINE AND IMMUNOTHERAPY STRATEGIES IMMUNE ADJUVANTS HETEROLOGOUS PRIME-BOOST VACCINATION IN TUMOR IMMUNOTHERAPY PEPTIDE-BASED VACCINES ANTIBODY-INDUCING CANCER VACCINES AGAINST CELL-SURFACE CARBOHYDRATE ANTIGENS ANTI-IDIOTYPE VACCINES CONTENTS POX VIRAL VACCINES UTILITY OF ADENOVIRUS-BASED VECTORS FOR MULTIPLE CANCER VACCINE APPROACHES ALPHAVIRAL-BASED STRATEGIES FOR THE IMMUNOTHERAPY OF CANCER DNA VACCINES WHOLE-CELL VACCINES GENE-MODIFIED TUMOR-CELL VACCINES HAPTEN-MODIFIED TUMOR VACCINES CHAPERONE PROTEINS/HEAT SHOCK PROTEINS AS ANTICANCER VACCINES DENDRITIC CELL VACCINES EXOSOMES FOR IMMUNOTHERAPY OF CANCER IMMUNOCYTOKINES FOR CANCER IMMUNOTHERAPY T-CELL ADOPTIVE IMMUNOTHERAPY PART III: TUMOR-SPECIFIC VACCINE DEVELOPMENT MELANOMA VACCINES ALLOGENIC MELANOMA LYSATE VACCINES RENAL CANCER VACCINES VACCINES FOR HEMATOLOGICAL MALIGNANCIES VACCINES FOR THE IMMUNOTHERAPY OF PROSTATE CANCER VACCINE THERAPY FOR BREAST AND OVARIAN CANCERS VACCINE THERAPY FOR GASTROINTESTINAL CANCERS VACCINES FOR LUNG CANCER VACCINES FOR OTHER TUMORS PART IV: CLINICAL TRIALS AND IMMUNE ANALYSES CLINICAL TRIAL DESIGNS FOR THERAPEUTIC VACCINE STUDIES ANALYSIS OF CELLULAR IMMUNE RESPONSES IN CANCER VACCINE TRIALS ANALYSIS OF HUMORAL IMMUNE RESPONSES IN VACCINE TRIALS REGULATORY ISSUES AFFECTING TUMOR VACCINES