MOLECULAR BIOLOGY IN CELL PATHOLOGY
A Pathology of Alzheimer’s Disease 1 Amyloid Morphology and Pathology of Alzheimer’s Disease 2 2 The Tau Proteins in Alzheimer’s Disease 15 B The Genetics of Familial Alzheimer’s Disease 3 Mutations in Three Genes are Associated with Early Onset Alzheimer’s Disease 44 C Molecular and Cellular Biology of the ?-Amyloid Precursor Protein and Amyloid ?- Peptide 4 The Biological Activities and Function of the Amyloid Precursor Protein of Alzheimer’s Disease 70 5 Proteolytic Processing of the ?-Amyloid Precursor Protein 90 6 Biosynthesis of APP and A?: Multiple Pathways for the Generation of Intracellular A? 105 7 The Cell Biology of Amyloid Precursor Protein 128 8 The Role of Amyloid ?-Peptide Terminating at Amino Acid 42 in Early Onset Alzheimer’s Disease 147 9 The Biophysics of Amyloid ?-Protein Fibrillogenesis 156 D The Presenilin Genes 10 The Molecular Biology of Presenilin 1 185 11 Molecular Biology of Presenilin 2 199 12 Presenilin Proteins and their Role in Development and Notch Signaling 210 13 The Processing of the Amyloid-Precursor-Protein (APP) in Presenilin-1 Deficient Neurons 226 14 Presenilins and their Role in Apoptosis 239 15 The Phosphorylation of Presenilin Proteins 269 E Role of Risk Factors in Alzheimer’s Disease 16 APOE and its Role in Late Onset Alzheimer’s Disease 281 F Transgenic Models for Alzheimer’s Disease 17 Transgenic Animal Models in the Development of Therapeutic Strategies for Alzheimer’s Disease 298 18 Presenilins in Transgenic Mice 317