WHAT WOULD HUXLEY MAKE OF PRION DISEASES?

By KAREN LOPEZ

CONTENTS 1 WHAT WOULD THOMAS HENRY HUXLEY HAVE MADE OF PRION DISEASES? 2 PRION PROTEIN AS COPPER-BINDING PROTEIN AT THE SYNAPSE 3 A FUNCTION FOR THE PRION PROTEIN? 4 PRION PROTEIN PEPTIDE AGENTS OF DEATH FOR NEURONS 5 CHARACTERIZATION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE STRAINS/ISOLATES BY IMMUNOCHEMICAL ANALYSIS OF PRPSC 6 DIFFERENTIAL TARGETING OF NEURONS BY PRION STRAINS 7 TRANSGENIC STUDIES OF PRION DISEASES 8 PRIONS: FROM NEUROGRAFTS TO NEUROINVASION 9 CELLULAR AND TRANSGENIC MODELS OF FAMILIAL PRION DISEASES 10 CENTRAL NERVOUS SYSTEM INFLAMMATION AND PRION DISEASE PATHOGENESIS 11 THE ELECTRONEUROPATHOLOGY OF PRION DISEASE 12 TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY NEUROBIOLOGY AND ULTRASTRUCTURE SUGGESTS EXTRACELLULAR PRPSC CONVERSION CONSISTENT WITH CLASSICAL AMYLOIDOSIS 13 CONFORMATION AS THERAPEUTIC TARGET IN THE PRIONOSES AND OTHER NEURODEGENERATIVE CONDITIONS 14 PRIONS OF YEAST FROM CYTOPLASMIC GENES TO HERITABLE AMYLOIDOSIS