APOPTOSIS: PHYSIOLOGY AND PATHOLOGY
CONTENTS I GENERAL PRINCIPLES OF CELL DEATH 1 HUMAN CASPASES – APOPTOSIS AND IN?AMMATION SIGNALING PROTEASES 2 INHIBITOR OF APOPTOSIS PROTEINS 3 DEATH DOMAIN–CONTAINING RECEPTORS – DECISIONS BETWEEN SUICIDE AND FIRE 4 MITOCHONDRIA AND CELL DEATH 5 THE CONTROL OF MITOCHONDRIAL APOPTOSIS BY THE BCL-2 FAMILY 6 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CELL DEATH AND CELL SURVIVAL 7 AUTOPHAGY – THE LIAISON BETWEEN THE LYSOSOMAL SYSTEM AND CELL DEATH 8 CELL DEATH IN RESPONSE TO GENOTOXIC STRESS AND DNA DAMAGE 9 CERAMIDE AND LIPID MEDIATORS IN APOPTOSIS 10 CYTOTOXIC GRANULES HOUSE POTENT PROAPOPTOTIC TOXINS CRITICAL FOR ANTIVIRAL RESPONSES AND IMMUNE HOMEOSTASIS II CELL DEATH IN TISSUES AND ORGANS 11 CELL DEATH IN NERVOUS SYSTEM DEVELOPMENT AND NEUROLOGICAL DISEASE 12 ROLE OF PROGRAMMED CELL DEATH IN NEURODEGENERATIVE DISEASE 13 IMPLICATIONS OF NITROSATIVE STRESS-INDUCED PROTEIN MISFOLDING IN NEURODEGENERATION 14 MITOCHONDRIAL MECHANISMS OF NEURAL CELL DEATH IN CEREBRAL ISCHEMIA 15 CELL DEATH IN SPINAL CORD INJURY – AN EVOLVING TAXONOMY WITH THERAPEUTIC PROMISE 16 APOPTOSIS AND HOMEOSTASIS IN THE EYE 17 CELL DEATH IN THE INNER EAR 19 CONTRIBUTION OF APOPTOSIS TO PHYSIOLOGIC REMODELING OF THE ENDOCRINE PANCREAS AND PATHOPHYSIOLOGY OF DIABETES 20 APOPTOSIS IN THE PHYSIOLOGY AND DISEASES OF THE RESPIRATORY TRACT 21 REGULATION OF CELL DEATH IN THE GASTROINTESTINAL TRACT 22 APOPTOSIS IN THE KIDNEY 23 PHYSIOLOGIC AND PATHOLOGICAL CELL DEATH IN THE MAMMARY GLAND 25 APOPTOTIC SIGNALING IN MALE GERM CELLS 26 CELL DEATH IN THE CARDIOVASCULAR SYSTEM 28 CELL DEATH IN THE SKIN 29 APOPTOSIS AND CELL SURVIVAL IN THE IMMUNE SYSTEM 31 APOPTOTIC CELL DEATH IN SEPSIS 32 HOST–PATHOGEN INTERACTIONS 34 CAENORHABDITIS ELEGANS AND APOPTOSIS 35 APOPTOTIC CELL DEATH IN DROSOPHILA 36 ANALYSIS OF CELL DEATH IN ZEBRA?SH