APOPTOSIS, SENESCENCE, AND CANCER

By X. PANAO

CONTENTS PART I: APOPTOSIS AND ALTERNATIVE MODES OF CELL DEATH THE INTRINSIC PATHWAY OF APOPTOSIS THE EXTRINSIC PATHWAY OF APOPTOSIS EVALUATING THE IMPORTANCE OF APOPTOSIS AND OTHER DETERMINANTS OF CELL DEATH AND SURVIVAL MITOTIC CATASTROPHE AUTOPHAGY AND AUTOPHAGIC CELL DEATH REGULATION AND FUNCTION OF DETACHMENT-INDUCED CELL DEATH (ANOIKIS) IN CANCER PROGRESSION AND METASTASIS PART II: TELOMERES AND TELOMERASE, SENESCENCE, GENOMIC INSTABILITY, AND TUMORIGENESIS STRUCTURE AND FUNCTION OF THE TELOMERE OVERVIEW OF SENESCENCE CONTRIBUTIONS OF TELOMERASE TO TUMORIGENESIS THE ROLE OF TELOMERES IN GENOMIC INSTABILITY PART III: DNA DAMAGE RESPONSE, SIGNALING PATHWAYS, AND TUMORIGENESIS OVERVIEW OF THE DNA DAMAGE CHECKPOINT: ATM AND ATR INTERACTIONS BETWEEN MYC- AND CYCLIN-DEPENDENT KINASE INHIBITORS IN CANCER INTERPLAY BETWEEN H2AX AND 53BP1 PATHWAYS IN DNA DOUBLE-STRAND BREAK REPAIR RESPONSE DNA-DEPENDENT PROTEIN KINASE IN REPAIR, APOPTOSIS, TELOMERE MAINTENANCE, AND CHEMOTHERAPY PART IV: RESISTANCE AND SENSITIZATION RESISTANCE/SIGNALING PATHWAYS CERAMIDE AND MULTIDRUG RESISTANCE CHEMO- AND RADIOSENSITIZATION THROUGH INHIBITION OF PI3K/AKT SIGNALING THE ADVANCEMENT OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS IN CANCER THERAPY PART V: ESTABLISHED CANCER THERAPIES ANTIMETABOLITES TOPOISOMERASE I POISONS AND APOPTOTIC TOPOISOMERASE I-DNA COMPLEXES PERTURBATIONS OF CELLULAR FUNCTIONS BY TOPOISOMERASE II INHIBITORS: ALL ROADS LEAD TO CELL DEATH? THE SIGNIFICANCE OF POLY-TARGETING IN APOPTOSIS INDUCTION BY ALKYLATING AGENTS AND PLATINUM DRUGS CONTRIBUTIONS OF APOPTOSIS AND SENESCENCE TO CYTOTOXICITY PRODUCED BY MICROTUBULE-STABILIZING AGENTS TYROSINE KINASE INHIBITORS PART VI: RECENT AND DEVELOPING CANCER THERAPIES MONOCLONAL ANTIBODIES IN LYMPHOMAS ROLE OF APOPTOSIS IN ANTI-ANGIOGENIC CANCER THERAPIES PHOTODYNAMIC THERAPY-INDUCED APOPTOSIS MODULATION OF TRAIL SIGNALING FOR CANCER THERAPY