ESSENTIALS OF APOPTOSIS

By V. NADAM

CONTENTS PART I: MOLECULES AND PATHWAYS OF APOPTOSIS 1 CASPASES: STRUCTURE, ACTIVATION PATHWAYS, AND SUBSTRATES 2 BCL-2 FAMILY PROTEINS: MASTER REGULATORS OF APOPTOSIS 3 INHIBITORS OF APOPTOSIS PROTEINS 4 STRUCTURAL BIOLOGY OF PROGRAMMED CELL DEATH 5 THE DEATH RECEPTOR FAMILY AND THE EXTRINSIC PATHWAY 6 THE MITOCHONDRIAL APOPTOSIS PATHWAY 7 FROM CASPASES TO ALTERNATIVE CELL-DEATH MECHANISMS PART II: APOPTOSIS IN ACTION 8 APOPTOSIS IN PLANTS, YEAST, AND BACTERIA 9 PROGRAMMED CELL DEATH IN C ELEGANS 10 CELL DEATH IN DROSOPHILA 11 CELL DEATH IN MAMMALIAN DEVELOPMENT 12 APOPTOSIS AND CANCER: PATHOGENIC AND THERAPEUTIC IMPLICATIONS 13 CELL DEATH IN IMMUNE, INFLAMMATORY, AND STRESS RESPONSES 14 CELL-DEATH MECHANISMS IN NEURODEGENERATIVE DISEASES: DIVERSITY AMONG CEREBRAL ISCHEMIA, PARKINSON'S DISEASE, AND HUNTINGTON'S DISEASE 15 APOPTOSIS IN ISCHEMIC DISEASE PART III: APPROACHES TO THE STUDY OF APOPTOSIS 16 ANALYSIS OF APOPTOSIS: BASIC PRINCIPLES AND PROCEDURES I MOLECULES AND PATHWAYS OF APOPTOSIS