THE REVIEW OF MEDICAL RESEARCH
TABLE OF CONTENTS CHAPTER 1 STUDIES ON HEART DISEASE 1 CHAPTER 2 NUTRITION AND HEART DISEASE 249 CHAPTER 3 ALTERNATIVE MEDICINE AND HEART DISEASE 267 CHAPTER 4 DISSERTATIONS ON HEART DISEASE 295 CHAPTER 5 CLINICAL TRIALS AND HEART DISEASE 303 CHAPTER 6 PATENTS ON HEART DISEASE 321 CHAPTER 7 BOOKS ON HEART DISEASE 355 CHAPTER 8 MULTIMEDIA ON HEART DISEASE 373 CHAPTER 9 PERIODICALS AND NEWS ON HEART DISEASE 377 CHAPTER 1 STUDIES ON HEART DISEASE OVERVIEW IN THIS CHAPTER WE WILL SHOW YOU HOW TO LOCATE PEER REVIEWED REFERENCES AND STUDIES ON HEART DISEASE THE COMBINED HEALTH INFORMATION DATABASE THE COMBINED HEALTH INFORMATION DATABASE SUMMARIZES STUDIES ACROSS NUMEROUS FEDERAL AGENCIES TO LIMIT YOUR INVESTIGATION TO RESEARCH STUDIES AND HEART DISEASE YOU WILL NEED TO USE THE ADVANCED SEARCH OPTIONS FIRST GO TO HTTP CHID NIH GOV INDEX HTML FROM THERE SELECT THE DETAILED SEARCH OPTION OR GO DIRECTLY TO THAT PAGE WITH THE FOLLOWING HYPERLINK HTTP CHID NIH GOV DETAIL DETAIL HTML THE TRICK IN EXTRACTING STUDIES IS FOUND IN THE DROP BOXES AT THE BOTTOM OF THE SEARCH PAGE WHERE YOU MAY REFINE YOUR SEARCH BY SELECT THE DATES AND LANGUAGE YOU PREFER AND THE FORMAT OPTION JOURNAL ARTICLE AT THE TOP OF THE SEARCH FORM SELECT THE NUMBER OF RECORDS YOU WOULD LIKE TO SEE WE RECOMMEND 100 AND CHECK THE BOX TO DISPLAY WHOLE RECORDS WE RECOMMEND THAT YOU TYPE HEART DISEASE OR SYNONYMS INTO THE FOR THESE WORDS BOX CONSIDER USING THE OPTION ANYWHERE IN RECORD TO MAKE YOUR SEARCH AS BROAD AS POSSIBLE IF YOU WANT TO LIMIT THE SEARCH TO ONLY A PARTICULAR FIELD SUCH AS THE TITLE OF THE JOURNAL THEN SELECT THIS OPTION IN THE SEARCH IN THESE FIELDS DROP BOX THE FOLLOWING IS WHAT YOU CAN EXPECT FROM THIS TYPE OF SEARCH KAWASAKI SYNDROME AND ACQUIRED HEART DISEASE SOURCE JOURNAL OF MUSCULOSKELETAL MEDICINE 19 2 65 68 74 75 FEBRUARY 2002 SUMMARY THIS JOURNAL ARTICLE PROVIDES HEALTH PROFESSIONALS WITH INFORMATION ON THE ETIOLOGY CLINICAL PRESENTATION DIAGNOSIS AND MANAGEMENT OF KAWASAKI SYNDROME KS THIS MULTISYSTEM INFLAMMATORY DISORDER OF UNKNOWN CAUSE MOST COMMONLY AFFECTS YOUNG CHILDREN ALTHOUGH THE CAUSE OF KS IS UNKNOWN AN UNDERLYING GENETIC PREDISPOSITION IS SUSPECTED BASED ON FAMILIAL CASES AND TWIN STUDIES WHEN KS IS NOT RECOGNIZED AND MANAGED EARLY CHILDREN WITH THE CONDITION MAY DEVELOP CORONARY ARTERY ANEURYSMS OR ASSOCIATED CARDIAC ABNORMALITIES KS IS THE LEADING CAUSE OF ACQUIRED HEART DISEASE IN CHILDREN ALL OF THE SIGNS AND SYMPTOMS OF KS ARE COMMON AND NONSPECIFIC WHICH COMPLICATES THE DIAGNOSIS ALTHOUGH THE DIAGNOSIS OFTEN INVOLVES UNCERTAINTY THE FOLLOWING CLINICAL FEATURES HELP DISTINGUISH KS FROM ILLNESSES THAT MIMIC 1 IT CHILDREN WITH KS ARE TYPICALLY QUITE IRRITABLE AND RELUCTANT TO BE EXAMINED CONJUNCTIVAL INJECTION SPARES THE ZONE IMMEDIATELY AROUND THE IRIS AND IS MORE PROMINENT ON THE SURFACE OF THE EYEBALL THAN ON THE MUCOSA OF THE EYELIDS PHARYNGEAL INFECTION IS TYPICALLY NONFOCAL LYMPHADENOPATHY IS GENERALLY UNILATERAL AND CONFINED TO THE ANTERIOR CERVICAL REGION THE RASH OFTEN HAS A PERINEAL CONFLUENCE AND IS VERY RARELY VESICULAR PALMAR AND PLANTAR ERYTHEMA MAY COME AND GO WITH THE FEVER AND DESQUAMATION TYPICALLY OCCURS 10 OR MORE DAYS AFTER THE FEVER BEGINS ALTHOUGH TESTS SUCH AS COMPLETE BLOOD CELL COUNT AND DIFFERENTIAL ERYTHROCYTE SEDIMENTATION RATE MICROSCOPIC URINALYSIS AND LIVER FUNCTION ARE INDIVIDUALLY NONSPECIFIC THEY CAN OFTEN BE HELPFUL IN MAKING THE DIAGNOSIS ASPIRIN HAS BEEN THE MOST WIDELY USED THERAPEUTIC AGENT BUT INTRAVENOUS IMMUNOGLOBULIN HAS BEEN DEMONSTRATED TO BE MORE EFFECTIVE ESPECIALLY FOR TREATING CHILDREN WITH HIGH OR RECURRENT FEVER 4 FIGURES 1 TABLE AND 17 REFERENCES AA M HELICOBACTER PYLORI INFECTION AS A RISK FACTOR FOR GASTROINTESTINAL SYMPTOMS IN PATIENTS USING ASPIRIN TO PREVENT ISHAEMIC HEART DISEASE SOURCE ALIMENTARY PHARMACOLOGY AND THERAPEUTICS 15 7 1055 1059 JULY 2001 CONTACT AVAILABLE FROM ALIMENTARY PHARMACOLOGY AND THERAPEUTICS BLACKWELL SCIENCE LTD OSNEY MEAD OXFORD OX2 OEL UK 44 0 1865 206206 FAX 44 0 1865 721205 E MAIL JOURNALS CS BLACKSCI CO UK WEBSITE WWW BLACKWELL SCIENCE COM SUMMARY ASPIRIN USE IN THE SECONDARY PREVENTION OF ISCHEMIC HEART DISEASE MAY PROVOKE GASTROINTESTINAL GI DISCOMFORT THIS ARTICLE REPORTS ON A STUDY UNDERTAKEN TO REGISTER GI SYMPTOMS AND COMPLICATIONS IN PATIENTS WITH CARDIOVASCULAR DISEASE USING ASPIRIN AND TO RELATE THESE SYMPTOMS TO INFECTION WITH H PYLORI BLOOD SAMPLES WERE OBTAINED FROM 398 CONSECUTIVE PATIENTS IN THE CORONARY CARE UNIT AT A HOSPITAL IN THE NETHERLANDS SAMPLES WERE ANALYZED FOR SERUM ANTIBODY LEVELS TO H PYLORI INFECTION QUESTIONNAIRES WERE SENT 2 WEEKS AFTER DISCHARGE TO ASSESS GI SYMPTOMS QUESTIONNAIRES WERE RETURNED BY 314 PATIENTS 79 PERCENT A TOTAL OF 183 OUT OF 314 PATIENTS 46 PERCENT REPORTED GI SYMPTOMS OF THE 238 PATIENTS USING 80 TO 100 MILLIGRAMS OF ASPIRIN DAILY 145 61 PERCENT RECORDED GI SYMPTOMS BESIDES ASPIRIN THE USE OF CALCIUM ANTAGONISTS WAS CORRELATED WITH GI SYMPTOMS OF THE 128 PATIENTS USING CALCIUM ANTAGONISTS 84 66 PERCENT REPORTED GI SYMPTOMS THE PREVALENCE OF GI SYMPTOMS IN H PYLORI POSITIVE AND NEGATIVE PATIENTS USING ASPIRIN WAS 48 PERCENT AND 52 PERCENT RESPECTIVELY THE AUTHORS CONCLUDE THAT 2 WEEKS AFTER DISCHARGE ALMOST 50 PERCENT OF THE PATIENTS WITH CARDIOVASCULAR DISEASE EXPERIENCED GI SYMPTOMS ESPECIALLY PATIENTS USING ASPIRIN OR CALCIUM ANTAGONISTS PATIENTS SEROPOSITIVE FOR H PYLORI AND USING ASPIRIN OR CALCIUM ANTAGONISTS DID NOT HAVE MORE GI DISCOMFORT COMPARED TO NON INFECTED PATIENTS 2 TABLES 16 REFERENCES LOST IN DARKNES DEPRESSION DIABETES AND HEART DISEASE SOURCE DIABETES FORECAST 56 5 44 46 MAY 2003 CONTACT AVAILABLE FROM AMERICAN DIABETES ASSOCIATION 1701 NORTH BEAUREGARD STREET ALEXANDRIA VA 22311 800 232 3472 WEBSITE WWW DIABETES ORG SUMMARY THIS ARTICLE HELPS READERS WITH DIABETES TO UNDERSTAND THE PROBLEM OF DEPRESSION AND THE RISKS THAT HAVING A CHRONIC DISEASE MAY CONTRIBUTE TO ANY LIKELIHOOD OF EXPERIENCING DEPRESSION THE AUTHOR NOTES THAT DEPRESSION MAY OCCUR AS A REACTION TO ILLNESS AND CHANGING SOCIAL CIRCUMSTANCES SUCH AS AFTER THE ONSET OF TYPE 1 DIABETES OR A DIVORCE BUT DEPRESSION ALSO SEEMS TO HAVE A GENETIC BASIS IN SOME PATIENTS THE AUTHOR BRIEFLY REVIEWS THE BIOLOGICAL BASIS OF DEPRESSION STRESS HORMONES DIAGNOSING 2 THE JOURNAL OF MEDICAL RESEARCH DEPRESSION AND TREATMENT OPTIONS ALTHOUGH DEPRESSION CAUSES SEVERE DYSFUNCTION MANY PEOPLE CAN BE SUCCESSFULLY TREATED BY A COMBINATION OF MEDICATION AND BY TESTED FORMS OF BEHAVIORAL THERAPY SUCH AS COGNITIVE BEHAVIORAL THERAPY WHICH IS A FORM OF COACHING REGULAR PHYSICAL EXERCISE HAS BEEN SHOWN TO REDUCE DEPRESSIVE SYMPTOMS EXERCISE ALSO IMPROVES BLOOD GLUCOSE CONTROL AND CARDIOVASCULAR FUNCTION NCEP DEFINED METABOLIC SYNDROME DIABETES AND PREVALENCE OF CORONARY HEART DISEASE AMONG NHANES III PARTICIPANTS AGE 50 YEARS AND OLDER SOURCE DIABETES 52 5 1210 1214 MAY 2003 CONTACT AVAILABLE FROM AMERICAN DIABETES ASSOCIATION 1701 NORTH BEAUREGARD STREET ALEXANDRIA VA 22311 800 232 3472 WEBSITE WWW DIABETES ORG SUMMARY ALTHOUGH THE INDIVIDUAL COMPONENTS OF THE METABOLIC SYNDROME ARE CLEARLY ASSOCIATED WITH INCREASED RISK FOR CORONARY HEART DISEASE CHD THE AUTHORS OF THIS STUDY WANTED TO QUANTIFY THE INCREASED PREVALENCE OF CHD AMONG PEOPLE WITH METABOLIC SYNDROME THE AUTHORS USED THE THIRD NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY NHANES III TO CATEGORIZE ADULTS OVER 50 YEARS OF AGE BY PRESENCE OF METABOLIC SYNDROME WITH OR WITHOUT DIABETES METABOLIC SYNDROME IS VERY COMMON WITH APPROXIMATELY 44 PERCENT OF THE UNITED STATES POPULATION OVER 50 YEARS OF AGE MEETING THE CRITERIA IN CONTRAST DIABETES WITHOUT METABOLIC SYNDROME IS UNCOMMON 13 PERCENT OF THOSE WITH DIABETES OLDER AMERICANS OVER 50 YEARS OF AGE WITHOUT METABOLIC SYNDROME REGARDLESS OF DIABETES STATUS HAD THE LOWEST CHD PREVALENCE THE PREVALENCE OF CHD MARKEDLY INCREASED WITH THE PRESENCE OF METABOLIC SYNDROME AMONG PEOPLE WITH DIABETES THE PREVALENCE OF METABOLIC SYNDROME WAS VERY HIGH AND THOSE WITH DIABETES AND METABOLIC SYNDROME HAD THE HIGHEST PREVALENCE OF CHD 2 FIGURES 4 TABLES 31 REFERENCES HEART DISEASE AND DIABETES SOURCE CLINICAL DIABETES 21 1 10 JANUARY 2003 CONTACT AVAILABLE FROM AMERICAN DIABETES ASSOCIATION 1701 NORTH BEAUREGARD STREET ALEXANDRIA VA 22311 800 232 3472 WEBSITE WWW DIABETES ORG SUMMARY THIS BRIEF FACT SHEET REMINDS READERS OF THE CONNECTION BETWEEN HEART DISEASE AND DIABETES THE FACT SHEET NOTES THAT MANY CONDITIONS THAT INCREASE ONE S CHANGES OF GETTING HEART DISEASE ARE MORE COMMON IN PEOPLE WITH DIABETES THESE CONDITIONS INCLUDE CHOLESTEROL PROBLEMS HIGH BLOOD PRESSURE HYPERTENSION OVERWEIGHT AND BLOOD CLOTTING PROBLEMS HEART ATTACKS KNOWN IN THE MEDICAL COMMUNITY AS MYOCARDIAL INFARCTIONS ARE ONE OF THE MOST COMMON HEART CONDITIONS FOR MOST PEOPLE A HEART CONDITION LEADS TO SYMPTOMS SUCH AS CHEST PAIN OR PRESSURE JAW PAIN ARM PAIN SHORTNESS OF BREATH SWEATING AND POUNDING HEARTBEAT HOWEVER MANY PEOPLE WITH DIABETES AND HEART DISEASE DO NOT NOTICE ANY SYMPTOMS AT ALL THIS IS CALLED SILENT ISCHEMIA SILENT ISCHEMIA IS VERY DANGEROUS BECAUSE IT MAY PREVENT PATIENTS WITH HEART PROBLEMS FROM SEEKING MEDICAL CARE AND GETTING EARLY TREATMENT THE FACT SHEET LISTS COMMON RISK FACTORS FOR HEART DISEASE AND ENCOURAGES READERS WITH THOSE RISK FACTORS TO BE TESTED PROSPECTIVE STUDY OF OBESITY AND RISK OF CORONARY HEART DISEASE AMONG DIABETIC WOMEN SOURCE DIABETES CARE 25 7 1142 1148 JULY 2002 3 THE JOURNAL OF MEDICAL RESEARCH