NOVEL ANTICANCER DRUG PROTOCOLS

By SOPHIA GONZALEZ

BIOMARKER ASSAYS FOR PHOSPHORYLATED MAP KINASE ASSAYS FOR CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFYING INHIBITORS OF ATM AND ATR KINASE ACTIVITIES THE RAT AORTIC RING ASSAY FOR IN VITRO STUDY OF ANGIOGENESIS REAL TIME IN VIVO QUANTITATION OF TUMOR ANGIOGENESIS USE OF TUMOR-ACTIVATED HEPATIC STELLATE CELL AS A TARGET FOR THE PRECLINICAL TESTING OF ANTI-ANGIOGENIC DRUGS AGAINST HEPATIC TUMOR DEVELOPMENT CELL MOTILITY, ADHESION, HOMING, AND MIGRATION ASSAYS IN THE STUDIES OF TYROSINE KINASES INFL AMMATORY RESPONSE OF TUMOR-ACTIVATED HEPATIC SINUSOIDAL ENDOTHELIUM AS A TARGET FOR THE SCREENING OF METASTASIS CHEMOPREVENTIVE DRUGS BINDING ASSAY FOR SELECTINS IMMUNOCYTOKINE IMMUNOHISTOCHEMICAL DETERMINATION OF EGFR-TYROSINE KINASE INHIBITION IN CLINICAL SAMPLES IMMUNOHISTOCHEMICAL ASSAYS OF FARNESYLTRANSFERASE INHIBITION IN PATIENT SAMPLES ASSAYS FOR HSP90 AND INHIBITORS ASSAYS FOR PROTEASOME INHIBITION THE MAMMALIAN TWO-HYBRID ASSAY FOR DETECTION OF COACTIVATOR-NUCLEAR RECEPTOR INTERACTIONS PREPARATION OF DNA-PROTEIN COMPLEXES SUITABLE FOR SPECTROSCOPIC ANALYSIS ANTISENSE OLIGONUCLEOTIDE INHIBITORS OF MDM2 ONCOGENE EXPRESSION PHARMACOGENETIC ANALYSIS OF CLINICALLY RELEVANT GENETIC POLYMORPHISMS GENE EXPRESSION MICROARRAYS METHODS FOR ISOLATION AND GENETIC ANALYSIS OF CIRCULATING TUMOR DNA IN PATIENT PLASMA THE USE OF EARLY SEA URCHIN EMBRYOS IN ANTICANCER DRUG TESTING PET SCREENING OF ANTICANCER DRUGS ASSAYS FOR IN VITRO AND IN VIVO SYNERGY FLOW CYTOMETRIC METHODS FOR DETECTION AND QUANTIFI CATION OF APOPTOSIS ASSAYS FOR NEOPLASTIC CELL ENRICHMENT IN BONE MARROW SAMPLES