MOLECULAR APPROACHES TO IMMUNOLOGY
CONTENTS PART I VIRAL-SPECIFIC IMMUNOLOGICAL AND OTHER HOST RESPONSES STUDYING HOST IMMUNE RESPONSES AGAINST DUCK HEPATITIS B VIRUS INFECTION MEASUREMENT OF CELL-MEDIATED IMMUNE RESPONSE IN WOODCHUCKS STUDY OF LIVER-SPECIFIC EXPRESSION OF CYTOKINES DURING WOODCHUCK HEPATITIS VIRUS INFECTION INDUCTION OF ANTI-HEPATITIS B VIRUS IMMUNE RESPONSES THROUGH DNA IMMUNIZATION MONITORING GENE EXPRESSION USING DNA MICROARRAYS DURING HEPATITIS B VIRUS INFECTION DETERMINATION OF HEPATITIS B VIRUS-SPECIFIC CD8+ T-CELL ACTIVITY IN THE LIVER DETERMINING THE PRECURSOR FREQUENCY OF HBV NUCLEOCAPSID ANTIGEN-SPECIFIC T CELLS DETECTION AND CHARACTERIZATION OF VIRUS-SPECIFIC CD8+ T CELLS USING THE TETRAMER APPROACH IN VITRO ANALYSIS OF HEPATITIS B VIRUS SPECIFIC CD4+ T CELLS INDUCTION OF HUMORAL AND CELLULAR IMMUNE RESPONSES TO HEPATITIS DELTA VIRUS THROUGH DNA IMMUNIZATION IN BALB/C MICE PART II IN VITRO AND IN VIVO MODELS INFECTION OF PRIMARY CHIMPANZEE HEPATOCYTES WITH RECOMBINANT HEPATITIS D VIRUS PARTICLES: A SURROGATE MODEL FOR HEPATITIS B VIRUS STUDY OF THE ENDOCYTOSIS AND INTRACELLULAR LOCALIZATION OF SUBVIRAL PARTICLES OF HEPATITIS B VIRUS IN PRIMARY HEPATOCYTES THE TUPAIA MODEL FOR THE STUDY OF HEPATITIS B VIRUS: DIRECT INFECTION AND HBV GENOME TRANSDUCTION OF PRIMARY TUPAIA HEPATOCYTES DELIVERY OF HEPATITIS B VIRUS THERAPEUTIC AGENTS USING ASIALOGLYCOPROTEIN RECEPTOR–BASED LIVER-SPECIFIC TARGETING WOODCHUCK HEPATITIS VIRUS HEPATOCYTE CULTURE MODELS DUCK HEPATITIS B VIRUS PRIMARY HEPATOCYTE CULTURE MODEL ENHANCEMENT OF INFECTION OF HEPG2 CELLS IN CULTURE BY PREDIGESTION OF HEPADNAVIRUS WITH V8 PROTEASE CONSTRUCTION OF RECOMBINANT ADENOVIRUSES THAT PRODUCE INFECTIOUS HEPATITIS B VIRUS BACULOVIRUS-MEDIATED GENE TRANSFER FOR THE STUDY OF HEPATITIS B VIRUS TRANSGENIC HEPATITIS B VIRUS MOUSE MODEL IN THE STUDY OF CHEMOTHERAPY TRANSPLANTATION OF HUMAN HEPATOCYTES IN IMMUNODEFICIENT UPA MICE: A MODEL FOR THE STUDY OF HEPATITIS B VIRUS DUCK HEPATITIS B VIRUS MODEL IN THE STUDY OF HEPATITIS B VIRUS HEPATITIS B VIRUS TRANSGENIC SEVERE COMBINED IMMUNODEFICIENT MOUSE MODEL OF ACUTE AND CHRONIC LIVER DISEASE THE CHIMPANZEE MODEL: CONTRIBUTIONS AND CONSIDERATIONS FOR STUDIES OF HEPATITIS B VIRUS HEPATITIS B IN LIVER TRANSPLANT RECIPIENTS AS A SPECIAL MODEL OF ANTIVIRAL DRUG DEVELOPMENT HEPATITIS DELTA VIRUS TRANSFECTION FOR THE MOUSE IN VIVO MODEL HEPATITIS DELTA VIRUS RNA TRANSFECTION FOR THE CELL CULTURE MODEL PART III ANTIVIRAL TESTING AND CLINICAL STUDIES ANALYSIS OF HEPATITIS B VIRUS DYNAMICS AND ITS IMPACT ON ANTIVIRAL DEVELOPMENT GENOTYPING ANTI-HEPATITIS B VIRUS DRUG RESISTANCE A PARSIMONIOUS METHOD FOR SCREENING DRUG COMBINATIONS FOR ANTIHEPADNAVIRAL ACTIVITY USING A PARAMETRIC DOSE–RESPONSE SURFACE APPROACH HEPATITIS B VIRUS: WHERE ARE WE AND WHERE ARE WE GOING? DESIGNING STUDIES TO EVALUATE ANTI-HEPATITIS B VIRUS THERAPIES: FROM THE PERSPECTIVE OF STUDIES FOR THE REGISTRATION OF PHARMACEUTICAL PRODUCTS SPECIFIC CONSIDERATIONS IN THE DESIGN OF HEPATITIS B VIRUS CLINICAL STUDIES IN THE FAR EAST STUDYING THE TREATMENT OF CHRONIC HEPATITIS B VIRAL INFECTION IN SPECIAL POPULATIONS DESIGNING CLINICAL DEVELOPMENT PROGRAMS FOR ANTI-HEPATITIS B VIRUS DRUGS TESTING ANTIVIRALS AGAINST HEPATITIS DELTA VIRUS: FARNESYL TRANSFERASE INHIBITORS I VIRAL-SPECIFIC IMMUNOLOGICAL AND OTHER HOST RESPONSES