CHEMICAL ANALYSIS: TECHNICAL METHODS
PART I ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS 1 CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY 3 CHAPTER 2 19F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING 37 CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS 53 CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS 71 CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS 87 CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT 125 PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL 137 CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS 139 CHAPTER 8 MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS 175 CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES 209 PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY 253 CHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES 255 CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION 281 CHAPTER 12 PARALLEL HPLC IN HIGHTHROUGHPUT ANALYSIS AND PURIFICATION 307 PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY 321 CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION 323 CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION 351 CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS 369 CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES 407 CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOGDVALUES BY LC/MS METHOD 435