TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY

By SUSAN JACKSON

CONTENTS CHAPTER POLYCYCLIC AROMATIC HYDROCARBONS PHOSPHOROTHIONATE ESTERS 1 9 OPTICAL ISOMERISM 1 10 SYNTHETIC POLYMERS SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER THE BIOSPHERE 2 10 THE ANTHROSPHERE AND GREEN CHEMISTRY 2 10 1 GREEN CHEMISTRY REFERENCES SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER METABOLIC PROCESSES 3 9 1 ENERGY-YIELDING PROCESSES SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER USING ENERGY TO PUT MOLECULES TOGETHER: ANABOLIC REACTIONS METABOLISM AND TOXICITY 4 6 1 STEREOCHEMISTRY AND XENOBIOTICS METABOLISM SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER EFFECTS OF TOXICANTS ON POPULATIONS 5 10 EFFECTS OF TOXICANTS ON ECOSYSTEMS SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER PULMONARY EXPOSURE KINETIC AND NONKINETIC TOXICOLOGY 6 9 1 KINETIC TOXICOLOGY 6 10 RECEPTORS AND TOXIC SUBSTANCES 6 10 1 RECEPTORS 6 11 PHASES OF TOXICITY 6 12 TOXI?CATION AND DETOXI?CATION 6 12 1 SYNERGISM, POTENTIATION, AND ANTAGONISM 6 13 BEHAVIORAL AND PHYSIOLOGICAL RESPONSES 6 13 1 VITAL SIGNS 6 13 2 SKIN SYMPTOMS 6 13 3 ODORS 6 13 4 EYES 6 13 5 MOUTH 6 13 6 GASTROINTESTINAL TRACT 6 13 7 CENTRAL NERVOUS SYSTEM 6 14 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS REFERENCES SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER PHASE II REACTIONS OF TOXICANTS 7 4 1 CONJUGATION BY GLUCURONIDES 7 4 2 CONJUGATION BY GLUTATHIONE IONIZING RADIATION REFERENCES QUESTIONS AND PROBLEMS CHAPTER TOXICOGENOMICS 8 6 1 GENETIC SUSCEPTIBILITY TO TOXIC EFFECTS OF PHARMACEUTICALS REFERENCES SUPPLEMENTARY REFERENCE QUESTIONS AND PROBLEMS CHAPTER BLOOD AND THE CARDIOVASCULAR SYSTEM 9 5 1 BLOOD 9 5 2 HYPOXIA 9 5 3 LEUKOCYTES AND LEUKEMIA REPRODUCTIVE SYSTEM 9 10 DEVELOPMENTAL TOXICOLOGY AND TERATOLOGY 9 10 1 THALIDOMIDE 9 10 2 ACCUTANE 9 10 3 FETAL ALCOHOL SYNDROME 9 11 KIDNEY AND BLADDER REFERENCES SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER IODINE FISSION PRODUCTS REFERENCES SUPPLEMENTARY REFERENCE QUESTIONS AND PROBLEMS CHAPTER SULFURIC ACID MISCELLANEOUS INORGANIC SULFUR COMPOUNDS REFERENCES QUESTIONS AND PROBLEMS CHAPTER TOXICOLOGY OF ORGANOLEAD COMPOUNDS 12 10 ORGANOARSENIC COMPOUNDS 12 10 1 ORGANOARSENIC COMPOUNDS FROM BIOLOGICAL PROCESSES 12 10 2 SYNTHETIC ORGANOARSENIC COMPOUNDS 12 10 3 TOXICITIES OF ORGANOARSENIC COMPOUNDS 12 11 ORGANOSELENIUM AND ORGANOTELLURIUM COMPOUNDS 12 11 1 ORGANOSELENIUM COMPOUNDS 12 11 2 ORGANOTELLURIUM COMPOUNDS REFERENCES SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER PENTANE THROUGH OCTANE PAH METABOLISM REFERENCES QUESTIONS AND PROBLEMS CHAPTER TOXICOLOGICAL CONSIDERATIONS 14 10 ESTERS 14 10 1 TOXICITIES OF ESTERS REFERENCES QUESTIONS AND PROBLEMS CHAPTER BIPYRIDILIUM COMPOUNDS 15 10 ALKALOIDS REFERENCES QUESTIONS AND PROBLEMS CHAPTER TOXICITY OF TCDD HEXACHLOROPHENE REFERENCES QUESTIONS AND PROBLEMS CHAPTER ORGANICALLY BOUND SELENIUM REFERENCES QUESTIONS AND PROBLEMS CHAPTER PHOSPHOROTHIONATE INSECTICIDES ORGANOPHOSPHORUS MILITARY POISONS REFERENCES SUPPLEMENTARY REFERENCE QUESTIONS AND PROBLEMS CHAPTER NONREPTILE ANIMAL TOXINS REFERENCES SUPPLEMENTARY REFERENCES QUESTIONS AND PROBLEMS CHAPTER ANALYSIS OF XENOBIOTICS 20 1 INTRODUCTION 20 2 INDICATORS OF EXPOSURE TO XENOBIOTICS 20 3 DETERMINATION OF METALS