MOLECULAR BIOLOGY OF THE ISLETS OF LANGERHANS

By ROBERT JONES

CONTENTS MICROSCOPIC ANATOMY OF THE HUMAN ISLET OF LANGERHANS THE COMPARATIVE ANATOMY OF ISLETS APPROACHES FOR IMAGING ISLETS: RECENT ADVANCES AND FUTURE PROSPECTS ISLET CELL DEVELOPMENT HIGH FAT PROGRAMMING OF ?-CELL FAILURE NUTRIENT REGULATION OF INSULIN SECRETION AND ?-CELL FUNCTIONAL INTEGRITY ELECTROPHYSIOLOGY OF ISLET CELLS ATP-SENSITIVE POTASSIUM CHANNELS IN HEALTH AND DISEASE ROLE OF MITOCHONDRIA IN ?-CELL FUNCTION AND DYSFUNCTION BASEMENT MEMBRANE IN PANCREATIC ISLET FUNCTION CALCIUM SIGNALING IN THE ISLETS ELECTRICAL BURSTING, CALCIUM OSCILLATIONS, AND SYNCHRONIZATION OF PANCREATIC ISLETS CYCLIC AMP SIGNALING IN PANCREATIC ISLETS EXOCYTOSIS IN ISLET ?-CELLS THE NOVEL ROLES OF GLUCAGON-LIKE PEPTIDE-1, ANGIOTENSIN II, AND VITAMIN D IN ISLET FUNCTION PROTEOMICS AND ISLET RESEARCH WNT SIGNALING IN PANCREATIC ISLETS MOLECULAR PATHWAYS UNDERLYING THE PATHOGENESIS OF PANCREATIC ?-CELL DYSFUNCTION MECHANISMS OF PANCREATIC ?-CELL APOPTOSIS IN DIABETES AND ITS THERAPIES ?-CELL FUNCTION IN OBESE-HYPERGLYCEMIC MICE [OB/OB MICE] ISLET STRUCTURE AND FUNCTION IN THE GK RAT THE ?-CELL IN HUMAN TYPE 2 DIABETES CLINICAL APPROACHES TO PRESERVE ?-CELL FUNCTION IN DIABETES IMMUNOLOGY OF ?-CELL DESTRUCTION TOLL-LIKE RECEPTORS AND TYPE 1 DIABETES PREVENTION OF ?-CELL DESTRUCTION IN AUTOIMMUNE DIABETES: CURRENT APPROACHES AND FUTURE PROSPECTS IN VIVO REGENERATION OF INSULIN-PRODUCING ?-CELLS CUSTOMIZED CELL-BASED TREATMENT OPTIONS TO COMBAT AUTOIMMUNITY AND RESTORE ?-CELL FUNCTION IN TYPE DIABETES MELLITUS: CURRENT PROTOCOLS AND FUTURE PERSPECTIVES THE PROGRAMMABLE CELL OF MONOCYTIC ORIGIN (PCMO): A POTENTIAL ADULT STEM/PROGENITOR CELL SOURCE FOR THE GENERATION OF ISLET CELLS ISLET ISOLATION FOR CLINICAL TRANSPLANTATION HUMAN ISLET AUTOTRANSPLANTATION: THE TRAIL THUS FAR AND THE HIGHWAY AHEAD MODULATION OF EARLY IN?AMMATORY REACTIONS TO PROMOTE ENGRAFTMENT AND FUNCTION OF TRANSPLANTED PANCREATIC ISLETS IN AUTOIMMUNE DIABETES SUCCESSES AND DISAPPOINTMENTS WITH CLINICAL ISLET TRANSPLANTATION ISLET CELL TUMOURS