AFFINITY MATURATION OF PHAGE-DISPLAYED PEPTIDE LIGANDS

By W. JONAO

2 QUALITATIVE COLORIMETRIC TESTS FOR SOLID PHASE SYNTHESIS SECTION II DIRECTED SORTING SPLIT-AND-POOL COMBINATORIAL SYNTHESIS 3 A REVIEW OF SOLID-PHASE ORGANIC SYNTHESIS ON SYNPHASE‘LANTERNS AND SYNPHASE‘CROWNS 4 DIRECTED SORTING APPROACH FOR THE SYNTHESIS OF LARGE COMBINATORIAL LIBRARIES OF DISCRETE COMPOUNDS 5 SPLIT-MIX SYNTHESIS USING MACROSCOPIC SOLID SUPPORT UNITS 6 THE ENCORE TECHNIQUE: A NOVEL APPROACH TO DIRECTED SPLIT-AND-POOL COMBINATORIAL SYNTHESIS SECTION III LINKERS AND THEIR APPLICATIONS 7 MULTIFUNCTIONAL LINKERS AS AN EFFICIENT TOOL FOR THE SYNTHESIS OF DIVERSE SMALL MOLECULE LIBRARIES: THE TRIAZENE ANCHORS 8 THE DEVELOPMENT AND APPLICATION OF TETRAFLUOROPHENOL-ACTIVATED RESINS FOR RAPID AMINE DERIVATIZATION 9 THE TRACELESS SOLID-PHASE SYNTHESIS OF ORGANIC MOLECULES 10 UNNATURAL DIAMINO ACID DERIVATIVES AS SCAFFOLDS FOR CREATING DIVERSITY AND AS LINKERS FOR SIMPLIFYING SCREENING IN CHEMICAL LIBRARIES SECTION IV MICROWAVE-ASSISTED SYNTHESIS 11 BUILDING DIHYDROPYRIMIDINE LIBRARIES VIA MICROWAVE-ASSISTED BIGINELLI MULTICOMPONENT REACTIONS 12 MICROWAVE-ASSISTED SOLID-PHASE ORGANIC SYNTHESIS (MA-SPOS) OF OXAZOLIDINONE ANTIMICROBIALS SECTION V OLIGOSACCHARIDE CHEMISTRY 13 AUTOMATED SYNTHESIS OF POLYSACCHARIDES 14 SOLID-PHASE OLIGOSACCHARIDE CHEMISTRY AND ITS APPLICATION TO LIBRARY SYNTHESIS SECTION VI PEPTIDE SYNTHESIS AND SCREENING 15 DESIGN, SYNTHESIS, SCREENING, AND DECODING OF ENCODED ONE-BEAD ONE-COMPOUND PEPTIDOMIMETIC AND SMALL MOLECULE COMBINATORIAL LIBRARIES 16 INTELLIGENT DESIGN IN COMBINATORIAL CHEMISTRY: USE OF DESIGNED PEPTIDE LIBRARIES TO EXPLORE SECONDARY AND TERTIARY STRUCTURES IN PEPTIDES AND PROTEINS 17 SYNTHESIS AND SCREENING OF ‘‘ONE-BEAD ONE- COMPOUND’’ COMBINATORIAL PEPTIDELIBRARIES 18 SYNTHETIC COMBINATORIAL LIBRARIES AS AN ALTERNATIVE STRATEGY FOR THE DEVELOPMENT OF NOVEL TREATMENTS FOR INFECTIOUS DISEASES SECTION VII POLYMER-ASSISTED APPROACHES 19 ADVANCES IN THE APPLICATIONS OF POLYMER- SUPPORTED REAGENTS FOR ORGANIC SYNTHESIS 20 ADVANCED POLYMER REAGENTS BASED ON ACTIVATED REACTANTS AND REACTIVE INTERMEDIATES: POWERFUL NOVEL TOOLS IN DIVERSITY-ORIENTED SYNTHESIS 21 SCAVENGER RESINS IN SOLUTION-PHASE COMBICHEM SECTION VIII SMALL MOLECULE AND HETEROCYCLE SYNTHESIS 22 CYCLATIVE CLEAVAGE STRATEGIES FOR THE SOLID- PHASE SYNTHESIS OF HETEROCYCLES AND NATURAL PRODUCTS 23 DERIVATIZATION REACTIONS OF HETEROCYCLIC SCAFFOLDS ON SOLID PHASE: TOOLS FOR THE SYNTHESIS OF DRUG-LIKE MOLECULE LIBRARIES 24 LIBRARY GENERATION VIA POST CONDENSATION MODIFICATIONS OF ISOCYANIDE-BASED MULTI- COMPONENT REACTIONS 25 MIXTURE-BASED COMBINATORIAL LIBRARIES: FROM PEPTIDES AND PEPTIDOMIMETICS TO SMALL MOLECULE ACYCLIC AND HETEROCYCLIC COMPOUNDS 26 NEW STRATEGIES FOR THE SOLID-PHASE SYNTHESIS OF HIGHLY FUNCTIONALIZED, SMALL MOLECULES: SEQUENTIAL NUCLEOPHILIC SUBSTITUTIONS ON POLYMER-BOUND POLYELECTROPHILES