PHYSIOLOGY OF EXCITABLE MEMBRANES
CONTENTS PART I STORE-OPERATED CALCIUM ENTRY HISTORICAL OVERVIEW OF STORE-OPERATED CA2+ ENTRY THE STIM1: ORAI INTERACTION THE TRPCS, ORAIS AND STIMS IN ER/PM JUNCTIONS TRP-NA+/CA2+ EXCHANGER COUPLING ROLE OF TRPC CHANNELS IN STORE-OPERATED CALCIUM ENTRY PHOSPHOLIPASE A 2 AS A MOLECULAR DETERMINANT OF STORE-OPERATED CALCIUM ENTRY EXTRACELLULAR CALCIUM HAS MULTIPLE TARGETS TO CONTROL CELL PROLIFERATION REGULATION OF PLATELET FUNCTION BY ORAI, STIM AND TRP PART II NON-CAPACITATIVE CA2+ ENTRY PATHWAYS ON THE ROLES OF THE TRANSIENT RECEPTOR POTENTIAL CANONICAL 3 (TRPC3) CHANNEL IN ENDOTHELIUM AND MACROPHAGES: IMPLICATIONS IN ATHEROSCLEROSIS 10 SECOND MESSENGER-OPERATED CALCIUM ENTRY THROUGH TRPC6 11 TRANSIENT RECEPTOR POTENTIAL CANONICAL 7 (TRPC7), 12 CALCIUM ENTRY THROUGH THERMOSENSORY CHANNELS 13 CALCIUM SIGNALLING THROUGH LIGAND-GATED ION CHANNELS SUCH AS P2X1 RECEPTORS IN THE PLATELET AND OTHER NON-EXCITABLE CELLS PART III ROLE OF CELLULAR MICRODOMAINS AND ORGANELLES IN CALCIUM ENTRY 14 THE CALCIUM ENTRY-CALCIUM REFILLING COUPLING 15 MICRODOMAINS ASSOCIATED TO LIPID RAFTS 16 ROLE OF SCAFFOLDING PROTEINS IN THE REGULATION OF TRPC-DEPENDENT CALCIUM ENTRY 17 MODULATION OF CALCIUM ENTRY BY MITOCHONDRIA 18 MODULATION OF CALCIUM ENTRY BY THE ENDO- LYSOSOMAL SYSTEM 19 REMODELING OF CALCIUM ENTRY PATHWAYS IN CANCER