MOLECULAR BIOLOGY FOR COMPUTER SCIENTISTS
CHAPTER 1 MOLECULAR BIOLOGY FOR COMPUTER SCIENTISTS CHAPTER 2 THE COMPUTATIONAL LINGUISTICS OF BIOLOGICAL SEQUENCES CHAPTER 3 NEURAL NETWORKS, ADAPTIVE OPTIMIZATION, AND RNA SECONDARY STRUCTURE PREDICTION CHAPTER 4 PREDICTING PROTEIN STRUCTURAL FEATURES WITH ARTIFICIAL NEURAL NETWORKS CHAPTER 5 DEVELOPING HIERARCHICAL REPRESENTATIONS FOR PROTEIN STRUCTURES: AN INCREMENTAL APPROACH CHAPTER 6 INTEGRATING AI WITH SEQUENCE ANALYSIS CHAPTER 7 PLANNING TO LEARN ABOUT PROTEIN STRUCTURE CHAPTER 8 A QUALITATIVE BIOCHEMISTRY AND ITS APPLICATION TO THE REGULATION OF THE TRYPTOPHAN OPERON CHAPTER 9 IDENTIFICATION OF QUALITATIVELY FEASIBLE METABOLIC PATHWAYS CHAPTER 10 KNOWLEDGE-BASED SIMULATION OF DNA METABOLISM: PREDICTION OF ACTION AND ENVISIONMENT OF PATHWAYS CHAPTER 11 AN AI APPROACH TO THE INTERPRETATION OF THE NMR SPECTRA OF PROTEINS CHAPTER 12 MOLECULAR SCENE ANALYSIS: CRYSTAL STRUCTURE DETERMINATION THROUGH IMAGERY CONTENTS C H A P T E R MOLECULAR BIOLOGY FOR COMPUTER SCIENTISTS “COMPUTERS ARE TO BIOLOGY WHAT MATHEMATICS IS TO PHYSICS” — HAROLD MOROWITZ ONE OF THE MAJOR CHALLENGES FOR COMPUTER SCIENTISTS WHO WISH TO WORK IN THE DOMAIN OF MOLECULAR BIOLOGY IS BECOMING CONVERSANT WITH THE DAUNTING INTRI- CACIES OF EXISTING BIOLOGICAL KNOWLEDGE AND ITS EXTENSIVE TECHNICAL VOCABU- LARY QUESTIONS ABOUT THE ORIGIN, FUNCTION, AND STRUCTURE OF LIVING SYSTEMS HAVE BEEN PURSUED BY NEARLY ALL CULTURES THROUGHOUT HISTORY, AND THE WORK OF THE LAST TWO GENERATIONS HAS BEEN PARTICULARLY FRUITFUL THE KNOWLEDGE OF LIV- ING SYSTEMS RESULTING FROM THIS RESEARCH IS FAR TOO DETAILED AND COMPLEX FOR ANY ONE HUMAN TO COMPREHEND AN ENTIRE SCIENTI?C CAREER CAN BE BASED IN THE STUDY OF A SINGLE BIOMOLECULE NEVERTHELESS, IN THE FOLLOWING PAGES, I ATTEMPT TO PROVIDE ENOUGH BACKGROUND FOR A COMPUTER SCIENTIST TO UNDERSTAND MUCH OF THE BIOLOGY DISCUSSED IN THIS BOOK THIS CHAPTER PROVIDES THE BRIEFEST OF OVERVIEWS; I CAN ONLY BEGIN TO CONVEY THE DEPTH, VARIETY, COMPLEXITY AND STUNNING BEAUTY OF THE UNIVERSE OF LIVING THINGS MUCH OF WHAT FOLLOWS IS NOT ABOUT MOLECULAR BIOLOGY PER SE IN ORDER TO