VENOMOUS ANIMALS AND THEIR VENOMS

By DAVID TAYLOR

CONTENTS I SECRETION AS A UNIFYING THEME SYNAPTIC VESICLE PROTEINS: A MOLECULAR STUDY SYNAPTIC VESICLE PROTEINS: A GENETIC APPROACH DISSECTION OF THE SECRETORY MACHINERY VESICULAR TRAFFICKING ON THE LATE SECRETORY PATHWAY IN THE BUDDING YEAST, S CEREVISIAE: YEAST AS A GENETIC TOOL IN WHICH TO EXPLORE PROTEIN EXPORT REGULATORY ROLES FOR LIPIDS IN VESICLE TRAFFICKING AND SECRETION FUSION PROTEINS AND THE FUSION EVENTS II CELL RECOGNITION AND MEMBRANE BINDING TETANUS TOXIN AS A VALUABLE PHARMACOLOGICAL TOOL FOR STUDYING POLYSIALOGANGLIOSIDES IN NEURONAL SIGNAL TRANSDUCTION MOLECULAR MECHANISMS OF THE ACTION OF CLOSTRIDIUM BOTULINUM TYPE B NEUROTOXIN ?-LATROTOXIN RECEPTORS III TOXIN’S MODE OF ACTION NEUROTOXINS AND SAFETY-LATCHES OF THE SECRETORY PROCESS BACTERIAL NEUROTOXINS IN INVERTEBRATES: APLYSIA AND THE DECIPHERING OF THE MODE OF ACTION OF CLOSTRIDIAL NEUROTOXINS CHROMAFFIN CELLS AS A SECRETORY SYSTEM: THE USE OF NEUROTOXINS EXTERNAL IONS AND ?-LATROTOXIN ACTION IV STRUCTURE AND FUNCTION—TOXINS AND THEIR TARGETS BOTULINUM NEUROTOXINS AND THEIR SUBSTRATES CLOSTRIDIAL NEUROTOXINS AS ENZYMES: STRUCTURE AND FUNCTION CESARE MONTECUCCO, ROSSELLA PELLIZZARI, ORNELLA ROSSETTO, GIAMPIETRO SCHIAVO, FIORELLA PURIFICATION, FUNCTION AND SELECTIVITY IN ?-LATROTOXIN V TOXINS AS PROBES OF CELL PHYSIOLOGY NEUROTOXINS, CYTOSKELETONS AND CALCIUM CHANNELS: FUNCTIONAL STUDIES AT MAMMALIAN SYNAPSES FORMED IN CULTURE THE SYNAPSINS AND NEUROTRANSMISSION MORPHOLOGICAL STUDIES OF THE SECRETORY MACHINERY USING NEUROTOXIN PROBES MEMBRANE FUSION PROTEIN ANNEXIN VII: A CA2+-ACTIVATED GTPASE TARGET FOR MASTOPARAN IN SECRETING CHROMAFFIN CELLS SECRETION AS A UNIFYING THEME